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10.1007/s11888-015-0269-2 http://scihub22266oqcxt.onion/10.1007/s11888-015-0269-2 C4591512!4591512!26441489     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Colorectal+Cancer+Rep 2015 ; 11 (3): 125-40 Nephropedia Template TP {{tp|p=26441489|t=2015. Immunotherapy of Metastatic Colorectal Cancer: Prevailing Challenges and New Perspectives |pdf=|usr=}}{{26441489}} gab.com Text Immunotherapy of Metastatic Colorectal Cancer: Prevailing Challenges and New Perspectives JO: Curr Colorectal Cancer Rep http://www.kidney.de/pget.php?&tw=1&pmid=26441489 #FOAvip Patients with recurring or metastatic colorectal cancer (mCRC) have strikingly low long-term survival, while conventional treatments such as chemotherapeutic intervention and radiation therapy marginally improve longevity. Although, many factors involving immunosurveillance and immunosuppression were recently validated as important for patient prognosis and care, a multitude of experimental immunotherapies designed to combat unresectable mCRC have, in few cases, successfully mobilized antitumor immune cells against malignancies, nor conclusively or consistently granted protection, complete remission, and/or stable disease from immunotherapy ? of which benefit less than 10% of those receiving therapy. After decades of progress, however, new insights into the mechanisms of immunosuppression, tolerance, and mutation profiling established novel therapies that circumvent these immunological barriers. This review underlines the most exciting methods to date that manipulate immune cells to curb mCRC, including adoptive cell therapy, dendritic cell vaccines, and checkpoint inhibitor antibodies ? of which hint at effective and enduring protection against disease progression and undetected micrometastases. Twit Text FOAVip Immunotherapy of Metastatic Colorectal Cancer: Prevailing Challenges and New Perspectives ????Curr Colorectal Cancer Rep http://www.kidney.de/pget.php?&tw=1&pmid=26441489 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26441489 #FOAvip English Wikipedia <ref>{{Cite pmid|26441489}}</ref> Immunotherapy of Metastatic Colorectal Cancer: Prevailing Challenges and New Perspectives #MMPMID26441489 Zumwalt TJ; Goel A Curr Colorectal Cancer Rep 2015[Jun]; 11 (3): 125-40 PMID26441489show ga Patients with recurring or metastatic colorectal cancer (mCRC) have strikingly low long-term survival, while conventional treatments such as chemotherapeutic intervention and radiation therapy marginally improve longevity. Although, many factors involving immunosurveillance and immunosuppression were recently validated as important for patient prognosis and care, a multitude of experimental immunotherapies designed to combat unresectable mCRC have, in few cases, successfully mobilized antitumor immune cells against malignancies, nor conclusively or consistently granted protection, complete remission, and/or stable disease from immunotherapy ? of which benefit less than 10% of those receiving therapy. After decades of progress, however, new insights into the mechanisms of immunosuppression, tolerance, and mutation profiling established novel therapies that circumvent these immunological barriers. This review underlines the most exciting methods to date that manipulate immune cells to curb mCRC, including adoptive cell therapy, dendritic cell vaccines, and checkpoint inhibitor antibodies ? of which hint at effective and enduring protection against disease progression and undetected micrometastases. äImmunotherapy of Metastatic Colorectal Cancer: Prevailing Challenges a(epmc).pdf DeepDyve Pubget Overpricing