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2015 ; 72
(2
): 210-9
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gab.com Text
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English Wikipedia
Non-traditional cytokines: How catecholamines and adipokines influence
macrophages in immunity, metabolism and the central nervous system
#MMPMID25703786
Barnes MA
; Carson MJ
; Nair MG
Cytokine
2015[Apr]; 72
(2
): 210-9
PMID25703786
show ga
Catecholamines and adipokines function as hormones; catecholamines as
neurotransmitters in the sympathetic nervous system, and adipokines as mediators
of metabolic processes. It has become increasingly clear, however, that both also
function as immunomodulators of innate and adaptive immune cells, including
macrophages. Macrophages can respond to, as well as produce their own
catecholamines. Dopamine, noradrenaline, and adrenaline are the most abundant
catecholamines in the body, and can induce both pro-inflammatory and
anti-inflammatory immune responses in macrophages, as well as non-immune
processes such as thermogenesis. Though they are responsive to adipokines,
particularly lipoproteins, leptin, and adiponectin, macrophages generally do not
synthesize their own adipokines, with the exception being resistin-like
molecules. Adipokines contribute to adverse metabolic and immune responses by
stimulating lipid accumulation, foam cell formation and pro-inflammatory cytokine
production in macrophages. Adipokines can also promote balance or resolution
during metabolic and immune processes by promoting reverse lipid transport and
expression of Th2 cytokines. This review will explore the mechanisms by which
catecholamines and adipokines influence macrophage function in neural pathways,
immunity and metabolism.