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10.1161/CIRCULATIONAHA.115.016871 http://scihub22266oqcxt.onion/10.1161/CIRCULATIONAHA.115.016871 C4590523!4590523 !26283655     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26283655 &cmd=llinks): Failed to open stream: HTTP request failed! 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Cryoballoon Versus Open Irrigated Radiofrequency Ablation in Patients With Paroxysmal Atrial Fibrillation: The Prospective, Randomized, Controlled, Noninferiority FreezeAF Study |pdf=|usr=}}{{26283655 }} gab.com Text Cryoballoon Versus Open Irrigated Radiofrequency Ablation in Patients With Paroxysmal Atrial Fibrillation: The Prospective, Randomized, Controlled, Noninferiority FreezeAF Study JO: Circulation http://www.kidney.de/pget.php?&tw=1&pmid=26283655 #FOAvip BACKGROUND: There is a lack of data on the comparative efficacy and procedural safety of open irrigated radiofrequency (RF) and cryoballoon catheter (CB) ablation for pulmonary vein isolation in patients with paroxysmal atrial fibrillation. METHODS AND RESULTS: In a prospective, noninferiority study, 315 patients were randomly assigned to RF (n=159) or CB (n=156) ablation. The primary end point was freedom from atrial arrhythmia with absence of persistent complications. Patients were largely comparable between groups with more vascular disease in the RF group (8.2% versus 2.6% for CB; P=0.028). The primary end point at 12 months was achieved by 70.7% with RF and 73.6% with CB (multiple procedure success), including 31 redo procedures in each group (19.5% of RF versus 19.9% of CB; P=0.933). For the intention-to-treat population, noninferiority of CB was revealed for the predefined inferiority margin (risk difference, 0.029; 95% confidence interval, -0.074 to 0.132; P<0.001). Rates at 6 months were 63.1% and 64.1% for the RF and CB groups (single procedure success), and noninferiority was confirmed (risk difference, 0.010; 95% confidence interval, -0.097 to 0.116; P=0.002). Periprocedural complications for the index procedure were more frequent in the CB group (5.0% RF, 12.2% CB; P=0.022) with a significant difference in phrenic nerve palsies (0% RF, 5.8% CB; P=0.002). CONCLUSION: This large, prospective, randomized, controlled study demonstrates noninferiority of CB ablation versus RF ablation for treating patients with paroxysmal atrial fibrillation. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00774566. Twit Text FOAVip Cryoballoon Versus Open Irrigated Radiofrequency Ablation in Patients With Paroxysmal Atrial Fibrillation: The Prospective, Randomized, Controlled, Noninferiority FreezeAF Study ????Circulation http://www.kidney.de/pget.php?&tw=1&pmid=26283655 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26283655 #FOAvip English Wikipedia <ref>{{Cite pmid|26283655 }}</ref> Cryoballoon Versus Open Irrigated Radiofrequency Ablation in Patients With Paroxysmal Atrial Fibrillation: The Prospective, Randomized, Controlled, Noninferiority FreezeAF Study #MMPMID26283655 Luik A ; Radzewitz A ; Kieser M ; Walter M ; Bramlage P ; Hörmann P ; Schmidt K ; Horn N ; Brinkmeier-Theofanopoulou M ; Kunzmann K ; Riexinger T ; Schymik G ; Merkel M ; Schmitt C Circulation 2015[Oct]; 132 (14 ): 1311-9 PMID26283655 show ga BACKGROUND: There is a lack of data on the comparative efficacy and procedural safety of open irrigated radiofrequency (RF) and cryoballoon catheter (CB) ablation for pulmonary vein isolation in patients with paroxysmal atrial fibrillation. METHODS AND RESULTS: In a prospective, noninferiority study, 315 patients were randomly assigned to RF (n=159) or CB (n=156) ablation. The primary end point was freedom from atrial arrhythmia with absence of persistent complications. Patients were largely comparable between groups with more vascular disease in the RF group (8.2% versus 2.6% for CB; P=0.028). The primary end point at 12 months was achieved by 70.7% with RF and 73.6% with CB (multiple procedure success), including 31 redo procedures in each group (19.5% of RF versus 19.9% of CB; P=0.933). For the intention-to-treat population, noninferiority of CB was revealed for the predefined inferiority margin (risk difference, 0.029; 95% confidence interval, -0.074 to 0.132; P<0.001). Rates at 6 months were 63.1% and 64.1% for the RF and CB groups (single procedure success), and noninferiority was confirmed (risk difference, 0.010; 95% confidence interval, -0.097 to 0.116; P=0.002). Periprocedural complications for the index procedure were more frequent in the CB group (5.0% RF, 12.2% CB; P=0.022) with a significant difference in phrenic nerve palsies (0% RF, 5.8% CB; P=0.002). CONCLUSION: This large, prospective, randomized, controlled study demonstrates noninferiority of CB ablation versus RF ablation for treating patients with paroxysmal atrial fibrillation. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00774566. |Adrenergic beta-Antagonists/therapeutic use [MESH] |Aged [MESH] |Anticoagulants/adverse effects/therapeutic use [MESH] |Atrial Fibrillation/drug therapy/epidemiology/*surgery [MESH] |Cardiovascular Diseases/epidemiology [MESH] |Catheter Ablation/adverse effects/instrumentation/*methods [MESH] |Combined Modality Therapy [MESH] |Comorbidity [MESH] |Cryosurgery/adverse effects/instrumentation/*methods [MESH] |Diabetes Mellitus/epidemiology [MESH] |Electrocardiography, Ambulatory [MESH] |Female [MESH] |Humans [MESH] |Imaging, Three-Dimensional [MESH] |Intraoperative Complications/epidemiology/etiology [MESH] |Male [MESH] |Middle Aged [MESH] |Pericardial Effusion/epidemiology/etiology [MESH] |Phrenic Nerve/injuries [MESH] |Postoperative Hemorrhage/chemically induced [MESH] |Prospective Studies [MESH] |Pulmonary Veins/*surgery [MESH] |Risk Assessment [MESH] |Sample Size [MESH] |Thrombophilia/drug therapy/etiology [MESH]Cryoballoon Versus Open Irrigated Radiofrequency Ablation in Patients (epmc).pdf DeepDyve Pubget Overpricing