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10.1093/jmcb/mjv049 http://scihub22266oqcxt.onion/10.1093/jmcb/mjv049 C4589950!4589950 !26160855     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26160855 &cmd=llinks): Failed to open stream: HTTP request failed! 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HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth |pdf=|usr=}}{{26160855 }} gab.com Text HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth JO: J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26160855 #FOAvip The reduced diameter of skeletal myofibres is a hallmark of several congenital myopathies, yet the underlying cellular and molecular mechanisms remain elusive. In this study, we investigate the role of HACD1/PTPLA, which is involved in the elongation of the very long chain fatty acids, in muscle fibre formation. In humans and dogs, HACD1 deficiency leads to a congenital myopathy with fibre size disproportion associated with a generalized muscle weakness. Through analysis of HACD1-deficient Labradors, Hacd1-knockout mice, and Hacd1-deficient myoblasts, we provide evidence that HACD1 promotes myoblast fusion during muscle development and regeneration. We further demonstrate that in normal differentiating myoblasts, expression of the catalytically active HACD1 isoform, which is encoded by a muscle-enriched splice variant, yields decreased lysophosphatidylcholine content, a potent inhibitor of myoblast fusion, and increased concentrations of ? C18 and monounsaturated fatty acids of phospholipids. These lipid modifications correlate with a reduction in plasma membrane rigidity. In conclusion, we propose that fusion impairment constitutes a novel, non-exclusive pathological mechanism operating in congenital myopathies and reveal that HACD1 is a key regulator of a lipid-dependent muscle fibre growth mechanism. Twit Text FOAVip HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth ????J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26160855 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26160855 #FOAvip English Wikipedia <ref>{{Cite pmid|26160855 }}</ref> HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth #MMPMID26160855 Blondelle J ; Ohno Y ; Gache V ; Guyot S ; Storck S ; Blanchard-Gutton N ; Barthélémy I ; Walmsley G ; Rahier A ; Gadin S ; Maurer M ; Guillaud L ; Prola A ; Ferry A ; Aubin-Houzelstein G ; Demarquoy J ; Relaix F ; Piercy RJ ; Blot S ; Kihara A ; Tiret L ; Pilot-Storck F J Mol Cell Biol 2015[Oct]; 7 (5 ): 429-40 PMID26160855 show ga The reduced diameter of skeletal myofibres is a hallmark of several congenital myopathies, yet the underlying cellular and molecular mechanisms remain elusive. In this study, we investigate the role of HACD1/PTPLA, which is involved in the elongation of the very long chain fatty acids, in muscle fibre formation. In humans and dogs, HACD1 deficiency leads to a congenital myopathy with fibre size disproportion associated with a generalized muscle weakness. Through analysis of HACD1-deficient Labradors, Hacd1-knockout mice, and Hacd1-deficient myoblasts, we provide evidence that HACD1 promotes myoblast fusion during muscle development and regeneration. We further demonstrate that in normal differentiating myoblasts, expression of the catalytically active HACD1 isoform, which is encoded by a muscle-enriched splice variant, yields decreased lysophosphatidylcholine content, a potent inhibitor of myoblast fusion, and increased concentrations of ? C18 and monounsaturated fatty acids of phospholipids. These lipid modifications correlate with a reduction in plasma membrane rigidity. In conclusion, we propose that fusion impairment constitutes a novel, non-exclusive pathological mechanism operating in congenital myopathies and reveal that HACD1 is a key regulator of a lipid-dependent muscle fibre growth mechanism. |Animals [MESH] |Cell Differentiation/genetics/physiology [MESH] |Cell Line [MESH] |Cell Membrane/genetics/*metabolism [MESH] |Dogs [MESH] |Female [MESH] |Humans [MESH] |Male [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Muscle Development/genetics/*physiology [MESH] |Muscle, Skeletal/metabolism [MESH] |Myoblasts/*cytology/metabolism [MESH]HACD1, a regulator of membrane composition and fluidity, promotes myob(epmc).pdf DeepDyve Pubget Overpricing