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10.1038/srep14816 http://scihub22266oqcxt.onion/10.1038/srep14816 C4589787!4589787 !26423352     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26423352 &cmd=llinks): Failed to open stream: HTTP request failed! 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The protein kinase 2 inhibitor tetrabromobenzotriazole protects against renal ischemia reperfusion injury |pdf=|usr=}}{{26423352 }} gab.com Text The protein kinase 2 inhibitor tetrabromobenzotriazole protects against renal ischemia reperfusion injury JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26423352 #FOAvip Protein kinase 2 (CK2) activation was reported to enhance reactive oxygen species production and activate the nuclear factor ?B (NF-?B) pathway. Because oxidative stress and inflammation are critical events for tissue destruction during ischemia reperfusion (I/R), we sought to determine whether CK2 was important in the renal response to I/R. Mice underwent 25 min of renal ischemia and were then reperfused. We confirmed an increased expression of CK2? during the reperfusion period, while expression of CK2? remained consistent. We administered tetrabromobenzotriazole (TBBt), a selective CK2? inhibitor before inducing I/R injury. Mice subjected to I/R injury showed typical patterns of acute kidney injury; blood urea nitrogen and serum creatinine levels, tubular necrosis and apoptosis, inflammatory cell infiltration and proinflammatory cytokine production, and oxidative stress were markedly increased when compared to sham mice. However, pretreatment with TBBt abolished these changes and improved renal function and architecture. Similar renoprotective effects of CK2? inhibition were observed for emodin. Renoprotective effects of CK2? inhibition were associated with suppression of NF-?B and mitogen activated protein kinase (MAPK) pathways. Taken together, these results suggest that CK2? mediates proapoptotic and proinflammatory signaling, thus the CK2? inhibitor may be used to prevent renal I/R injuries observed in clinical settings. Twit Text FOAVip The protein kinase 2 inhibitor tetrabromobenzotriazole protects against renal ischemia reperfusion injury ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26423352 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26423352 #FOAvip English Wikipedia <ref>{{Cite pmid|26423352 }}</ref> The protein kinase 2 inhibitor tetrabromobenzotriazole protects against renal ischemia reperfusion injury #MMPMID26423352 Ka SO ; Hwang HP ; Jang JH ; Hyuk Bang I ; Bae UJ ; Yu HC ; Cho BH ; Park BH Sci Rep 2015[Oct]; 5 (ä): 14816 PMID26423352 show ga Protein kinase 2 (CK2) activation was reported to enhance reactive oxygen species production and activate the nuclear factor ?B (NF-?B) pathway. Because oxidative stress and inflammation are critical events for tissue destruction during ischemia reperfusion (I/R), we sought to determine whether CK2 was important in the renal response to I/R. Mice underwent 25 min of renal ischemia and were then reperfused. We confirmed an increased expression of CK2? during the reperfusion period, while expression of CK2? remained consistent. We administered tetrabromobenzotriazole (TBBt), a selective CK2? inhibitor before inducing I/R injury. Mice subjected to I/R injury showed typical patterns of acute kidney injury; blood urea nitrogen and serum creatinine levels, tubular necrosis and apoptosis, inflammatory cell infiltration and proinflammatory cytokine production, and oxidative stress were markedly increased when compared to sham mice. However, pretreatment with TBBt abolished these changes and improved renal function and architecture. Similar renoprotective effects of CK2? inhibition were observed for emodin. Renoprotective effects of CK2? inhibition were associated with suppression of NF-?B and mitogen activated protein kinase (MAPK) pathways. Taken together, these results suggest that CK2? mediates proapoptotic and proinflammatory signaling, thus the CK2? inhibitor may be used to prevent renal I/R injuries observed in clinical settings. |Animals [MESH] |Apoptosis/drug effects/genetics [MESH] |Casein Kinase II/*antagonists & inhibitors/genetics/metabolism [MESH] |Extracellular Signal-Regulated MAP Kinases/metabolism [MESH] |Gene Expression [MESH] |Inflammation Mediators/metabolism [MESH] |Kidney Diseases/drug therapy/genetics/*metabolism/*pathology [MESH] |Male [MESH] |Mice [MESH] |Mitogen-Activated Protein Kinases/metabolism [MESH] |NF-kappa B/metabolism [MESH] |Oxidative Stress/drug effects [MESH] |Protein Kinase Inhibitors/*pharmacology [MESH] |Reperfusion Injury/drug therapy/genetics/*metabolism/*pathology [MESH] |Signal Transduction/drug effects [MESH]The protein kinase 2 inhibitor tetrabromobenzotriazole protects agains(epmc).pdf DeepDyve Pubget Overpricing