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10.1038/mto.2015.16 http://scihub22266oqcxt.onion/10.1038/mto.2015.16 C4589754!4589754 !26436134     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26436134 &cmd=llinks): Failed to open stream: HTTP request failed! 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Pediatric cancer gone viral Part II: potential clinical application of oncolytic herpes simplex virus-1 in children |pdf=|usr=}}{{26436134 }} gab.com Text Pediatric cancer gone viral Part II: potential clinical application of oncolytic herpes simplex virus-1 in children JO: Mol Ther Oncolytics http://www.kidney.de/pget.php?&tw=1&pmid=26436134 #FOAvip Oncolytic engineered herpes simplex viruses (HSVs) possess many biologic and functional attributes that support their use in clinical trials in children with solid tumors. Tumor cells, in an effort to escape regulatory mechanisms that would impair their growth and progression, have removed many mechanisms that would have protected them from virus infection and eventual virus-mediated destruction. Viruses engineered to exploit this weakness, like mutant HSV, can be safely employed as tumor cell killers, since normal cells retain these antiviral strategies. Many preclinical studies and early phase trials in adults demonstrated that oncolytic HSV can be safely used and are highly effective in killing tumor cells that comprise pediatric malignancies, without generating the toxic side effects of nondiscriminatory chemotherapy or radiation therapy. A variety of engineered viruses have been developed and tested in numerous preclinical models of pediatric cancers and initial trials in patients are underway. In Part II of this review series, we examine the preclinical evidence to support the further advancement of oncolytic HSV in the pediatric population. We discuss clinical advances made to date in this emerging era of oncolytic virotherapy. Twit Text FOAVip Pediatric cancer gone viral Part II: potential clinical application of oncolytic herpes simplex virus-1 in children ????Mol Ther Oncolytics http://www.kidney.de/pget.php?&tw=1&pmid=26436134 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26436134 #FOAvip English Wikipedia <ref>{{Cite pmid|26436134 }}</ref> Pediatric cancer gone viral Part II: potential clinical application of oncolytic herpes simplex virus-1 in children #MMPMID26436134 Friedman GK ; Beierle EA ; Gillespie GY ; Markert JM ; Waters AM ; Chen CY ; Denton NL ; Haworth KB ; Hutzen B ; Leddon JL ; Streby KA ; Wang PY ; Cripe TP Mol Ther Oncolytics 2015[]; 2 (ä): 15016- PMID26436134 show ga Oncolytic engineered herpes simplex viruses (HSVs) possess many biologic and functional attributes that support their use in clinical trials in children with solid tumors. Tumor cells, in an effort to escape regulatory mechanisms that would impair their growth and progression, have removed many mechanisms that would have protected them from virus infection and eventual virus-mediated destruction. Viruses engineered to exploit this weakness, like mutant HSV, can be safely employed as tumor cell killers, since normal cells retain these antiviral strategies. Many preclinical studies and early phase trials in adults demonstrated that oncolytic HSV can be safely used and are highly effective in killing tumor cells that comprise pediatric malignancies, without generating the toxic side effects of nondiscriminatory chemotherapy or radiation therapy. A variety of engineered viruses have been developed and tested in numerous preclinical models of pediatric cancers and initial trials in patients are underway. In Part II of this review series, we examine the preclinical evidence to support the further advancement of oncolytic HSV in the pediatric population. We discuss clinical advances made to date in this emerging era of oncolytic virotherapy. äPediatric cancer gone viral Part II: potential clinical application o(epmc).pdf DeepDyve Pubget Overpricing