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10.1371/journal.pone.0139484 http://scihub22266oqcxt.onion/10.1371/journal.pone.0139484 C4589536!4589536!26421725     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2015 ; 10 (9): ä Nephropedia Template TP {{tp|p=26421725|t=2015. A Magnetic Bead-Based Sensor for the Quantification of Multiple Prostate Cancer Biomarkers |pdf=|usr=}}{{26421725}} gab.com Text A Magnetic Bead-Based Sensor for the Quantification of Multiple Prostate Cancer Biomarkers JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26421725 #FOAvip Novel biomarker assays and upgraded analytical tools are urgently needed to accurately discriminate benign prostatic hypertrophy (BPH) from prostate cancer (CaP). To address this unmet clinical need, we report a piezeoelectric/magnetic bead-based assay to quantitate prostate specific antigen (PSA; free and total), prostatic acid phosphatase, carbonic anhydrase 1 (CA1), osteonectin, IL-6 soluble receptor (IL-6sr), and spondin-2. We used the sensor to measure these seven proteins in serum samples from 120 benign prostate hypertrophy patients and 100 Gleason score 6 and 7 CaP using serum samples previously collected and banked. The results were analyzed with receiver operator characteristic curve analysis. There were significant differences between BPH and CaP patients in the PSA, CA1, and spondin-2 assays. The highest AUC discrimination was achieved with a spondin-2 OR free/total PSA operation?the area under the curve was 0.84 with a p value below 10?6. Some of these data seem to contradict previous reports and highlight the importance of sample selection and proper assay building in the development of biomarker measurement schemes. This bead-based system offers important advantages in assay building including low cost, high throughput, and rapid identification of an optimal matched antibody pair. Twit Text FOAVip A Magnetic Bead-Based Sensor for the Quantification of Multiple Prostate Cancer Biomarkers ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26421725 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26421725 #FOAvip English Wikipedia <ref>{{Cite pmid|26421725}}</ref> A Magnetic Bead-Based Sensor for the Quantification of Multiple Prostate Cancer Biomarkers #MMPMID26421725 Jokerst JV; Chen Z; Xu L; Nolley R; Chang E; Mitchell B; Brooks JD; Gambhir SS PLoS One 2015[]; 10 (9): ä PMID26421725show ga Novel biomarker assays and upgraded analytical tools are urgently needed to accurately discriminate benign prostatic hypertrophy (BPH) from prostate cancer (CaP). To address this unmet clinical need, we report a piezeoelectric/magnetic bead-based assay to quantitate prostate specific antigen (PSA; free and total), prostatic acid phosphatase, carbonic anhydrase 1 (CA1), osteonectin, IL-6 soluble receptor (IL-6sr), and spondin-2. We used the sensor to measure these seven proteins in serum samples from 120 benign prostate hypertrophy patients and 100 Gleason score 6 and 7 CaP using serum samples previously collected and banked. The results were analyzed with receiver operator characteristic curve analysis. There were significant differences between BPH and CaP patients in the PSA, CA1, and spondin-2 assays. The highest AUC discrimination was achieved with a spondin-2 OR free/total PSA operation?the area under the curve was 0.84 with a p value below 10?6. Some of these data seem to contradict previous reports and highlight the importance of sample selection and proper assay building in the development of biomarker measurement schemes. This bead-based system offers important advantages in assay building including low cost, high throughput, and rapid identification of an optimal matched antibody pair. äA Magnetic Bead-Based Sensor for the Quantification of Multiple Prosta(epmc).pdf DeepDyve Pubget Overpricing