Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26308851
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Lab+Chip
2015 ; 15
(20
): 4020-31
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Programmable bio-nano-chip system: a flexible point-of-care platform for
bioscience and clinical measurements
#MMPMID26308851
McRae MP
; Simmons GW
; Wong J
; Shadfan B
; Gopalkrishnan S
; Christodoulides N
; McDevitt JT
Lab Chip
2015[Oct]; 15
(20
): 4020-31
PMID26308851
show ga
The development of integrated instrumentation for universal bioassay systems
serves as a key goal for the lab-on-a-chip community. The programmable
bio-nano-chip (p-BNC) system is a versatile multiplexed and multiclass chemical-
and bio-sensing system for bioscience and clinical measurements. The system is
comprised of two main components, a disposable cartridge and a portable analyzer.
The customizable single-use plastic cartridges, which now can be manufactured in
high volumes using injection molding, are designed for analytical performance,
ease of use, reproducibility, and low cost. These labcard devices implement high
surface area nano-structured biomarker capture elements that enable high
performance signaling and are index-matched to real-world biological specimens.
This detection modality, along with the convenience of on-chip fluid storage in
blisters and self-contained waste, represents a standard process to digitize
biological signatures at the point-of-care. A companion portable analyzer
prototype has been developed to integrate fluid motivation, optical detection,
and automated data analysis, and it serves as the human interface for complete
assay automation. In this report, we provide a systems-level perspective of the
p-BNC universal biosensing platform with an emphasis on flow control, device
integration, and automation. To demonstrate the flexibility of the p-BNC, we
distinguish diseased and non-case patients across three significant disease
applications: prostate cancer, ovarian cancer, and acute myocardial infarction.
Progress towards developing a rapid 7 minute myoglobin assay is presented using
the fully automated p-BNC system.