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10.1038/onc.2015.13 http://scihub22266oqcxt.onion/10.1038/onc.2015.13 C4589427!4589427!25823021     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogene 2015 ; 34 (45): 5635-47 Nephropedia Template TP {{tp|p=25823021|t=2015. Fibulin-3 is a Novel TGF-? pathway Inhibitor in the Breast Cancer Microenvironment |pdf=|usr=}}{{25823021}} gab.com Text Fibulin-3 is a Novel TGF- pathway Inhibitor in the Breast Cancer Microenvironment JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=25823021 #FOAvip TGF-? is an important regulator of breast cancer progression. However, how the breast cancer microenvironment regulates TGF-? signaling during breast cancer progression remains largely unknown. Here, we identified fibulin-3 as a secreted protein in the breast cancer microenvironment, which efficiently inhibits TGF-? signaling in both breast cancer cells and endothelial cells. Mechanistically, fibulin-3 interacts with the type I TGF-? receptor (T?RI) to block TGF-? induced complex formation of T?RI with the type II TGF-? receptor (T?RII) and subsequent downstream TGF-? signaling. Fibulin-3 expression decreases during breast cancer progression, with low fibulin-3 levels correlating with a poorer prognosis. Functionally, high fibulin-3 levels inhibited TGF-?-induced EMT, migration, invasion and endothelial permeability, while loss of fibulin-3 expression/function promoted these TGF-?-mediated effects. Further, restoring fibulin-3 expression in breast cancer cells inhibited TGF-? signaling, breast cancer cell EMT, invasion and metastasis in vivo. These studies provide a novel mechanism for how TGF-? signaling is regulated by the tumor microenvironment, and provide insight into targeting the TGF-? signaling pathway in human breast cancer patients. Twit Text FOAVip Fibulin-3 is a Novel TGF- pathway Inhibitor in the Breast Cancer Microenvironment ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=25823021 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25823021 #FOAvip English Wikipedia <ref>{{Cite pmid|25823021}}</ref> Fibulin-3 is a Novel TGF-? pathway Inhibitor in the Breast Cancer Microenvironment #MMPMID25823021 Tian H; Liu J; Chen J; Gatza ML; Blobe GC Oncogene 2015[Nov]; 34 (45): 5635-47 PMID25823021show ga TGF-? is an important regulator of breast cancer progression. However, how the breast cancer microenvironment regulates TGF-? signaling during breast cancer progression remains largely unknown. Here, we identified fibulin-3 as a secreted protein in the breast cancer microenvironment, which efficiently inhibits TGF-? signaling in both breast cancer cells and endothelial cells. Mechanistically, fibulin-3 interacts with the type I TGF-? receptor (T?RI) to block TGF-? induced complex formation of T?RI with the type II TGF-? receptor (T?RII) and subsequent downstream TGF-? signaling. Fibulin-3 expression decreases during breast cancer progression, with low fibulin-3 levels correlating with a poorer prognosis. Functionally, high fibulin-3 levels inhibited TGF-?-induced EMT, migration, invasion and endothelial permeability, while loss of fibulin-3 expression/function promoted these TGF-?-mediated effects. Further, restoring fibulin-3 expression in breast cancer cells inhibited TGF-? signaling, breast cancer cell EMT, invasion and metastasis in vivo. These studies provide a novel mechanism for how TGF-? signaling is regulated by the tumor microenvironment, and provide insight into targeting the TGF-? signaling pathway in human breast cancer patients. äFibulin-3 is a Novel TGF-? pathway Inhibitor in the Breast Cancer Micr(epmc).pdf DeepDyve Pubget Overpricing