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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 PLoS+One
2015 ; 10
(9
): e0138990
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The Cost-Effectiveness of Emergency Hormonal Contraception with Ulipristal
Acetate versus Levonorgestrel for Minors in France
#MMPMID26422259
Schmid R
PLoS One
2015[]; 10
(9
): e0138990
PMID26422259
show ga
OBJECTIVE: To evaluate the cost-effectiveness of ulipristal acetate and
levonorgestrel in minors in France, and analyze whether it is worthwhile to
provide ulipristal acetate to minors free of charge. METHODS: The
cost-effectiveness of two emergency contraceptive methods was compared based on a
decision-analytical model. Pregnancy rates, outcomes of unintended pregnancies,
and resource utilization were derived from the literature. Resources and their
costs were considered until termination or a few days after delivery.
Deterministic and probabilistic sensitivity analyses were performed. RESULTS: The
cost of an unintended pregnancy in a French minor is estimated to be 1,630 ?
(range 1,330 ? - 1,803 ?). Almost 4 million ? (3.1 ? - 13.7 ? million) in
unintended pregnancy spending in 2010 could have been saved by the use of
ulipristal acetate instead of levonorgestrel. The incremental cost of ulipristal
acetate compared to levonorgestrel is 3.30 ? per intake, or 418 ? per pregnancy
avoided (intake within 72 hours). In the intake within 24 hours subgroup,
ulipristal acetate was found to be more efficacious at a lower cost compared to
levonorgestrel. CONCLUSIONS: Ulipristal acetate dominates levonorgestrel when
taken within 24 hours after unprotected intercourse, i.e., it is more effective
at a lower cost. When taken within 72 hours, ulipristal acetate is a cost-
effective alternative to levonorgestrel, given that the cost of avoiding an
additional pregnancy with ulipristal acetate is less than the average cost of
these pregnancies. In the light of these findings, it is worthwhile to provide
free access to minors.