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2015 ; 12
(ä): 33
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Development of cryptococcal immune reconstitution inflammatory syndrome 41 months
after the initiation of antiretroviral therapy in an AIDS patient
#MMPMID26425133
Hashimoto H
; Hatakeyama S
; Yotsuyanagi H
AIDS Res Ther
2015[]; 12
(ä): 33
PMID26425133
show ga
Cryptococcal meningitis is one of the most lethal fungal infections in patients
with acquired immune deficiency syndrome (AIDS). The incidence of and mortality
from cryptococcal meningitis have markedly decreased since the introduction of
combination antiretroviral therapy (cART). However, despite its benefits, the
initiation of cART results in immune reconstitution inflammatory syndrome (IRIS)
in some patients. Although IRIS is occasionally difficult to distinguish from
relapse or treatment failure, the distinction is important because IRIS requires
a different treatment. Here, we present the case of a patient with AIDS who
developed symptoms of cryptococcal IRIS 41 months after starting cART. To the
best of our knowledge, the time between cART initiation and the onset of
cryptococcal IRIS in this patient is the longest that has been reported in the
literature.