Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.jbi.2012.04.011 http://scihub22266oqcxt.onion/10.1016/j.jbi.2012.04.011 C4589154!4589154 !22561026     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22561026 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\22561026 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biomed+Inform 2012 ; 45 (5 ): 827-34 Nephropedia Template TP {{tp|p=22561026 |t=2012. A knowledge-driven conditional approach to extract pharmacogenomics specific drug-gene relationships from free text |pdf=|usr=}}{{22561026 }} gab.com Text A knowledge-driven conditional approach to extract pharmacogenomics specific drug-gene relationships from free text JO: J Biomed Inform http://www.kidney.de/pget.php?&tw=1&pmid=22561026 #FOAvip An important task in pharmacogenomics (PGx) studies is to identify genetic variants that may impact drug response. The success of many systematic and integrative computational approaches for PGx studies depends on the availability of accurate, comprehensive and machine understandable drug-gene relationship knowledge bases. Scientific literature is one of the most comprehensive knowledge sources for PGx-specific drug-gene relationships. However, the major barrier in accessing this information is that the knowledge is buried in a large amount of free text with limited machine understandability. Therefore there is a need to develop automatic approaches to extract structured PGx-specific drug-gene relationships from unstructured free text literature. In this study, we have developed a conditional relationship extraction approach to extract PGx-specific drug-gene pairs from 20 million MEDLINE abstracts using known drug-gene pairs as prior knowledge. We have demonstrated that the conditional drug-gene relationship extraction approach significantly improves the precision and F1 measure compared to the unconditioned approach (precision: 0.345 vs. 0.11; recall: 0.481 vs. 1.00; F1: 0.402 vs. 0.201). In this study, a method based on co-occurrence is used as the underlying relationship extraction method for its simplicity. It can be replaced by or combined with more advanced methods such as machine learning or natural language processing approaches to further improve the performance of the drug-gene relationship extraction from free text. Our method is not limited to extracting a drug-gene relationship; it can be generalized to extract other types of relationships when related background knowledge bases exist. Twit Text FOAVip A knowledge-driven conditional approach to extract pharmacogenomics specific drug-gene relationships from free text ????J Biomed Inform http://www.kidney.de/pget.php?&tw=1&pmid=22561026 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22561026 #FOAvip English Wikipedia <ref>{{Cite pmid|22561026 }}</ref> A knowledge-driven conditional approach to extract pharmacogenomics specific drug-gene relationships from free text #MMPMID22561026 Xu R ; Wang Q J Biomed Inform 2012[Oct]; 45 (5 ): 827-34 PMID22561026 show ga An important task in pharmacogenomics (PGx) studies is to identify genetic variants that may impact drug response. The success of many systematic and integrative computational approaches for PGx studies depends on the availability of accurate, comprehensive and machine understandable drug-gene relationship knowledge bases. Scientific literature is one of the most comprehensive knowledge sources for PGx-specific drug-gene relationships. However, the major barrier in accessing this information is that the knowledge is buried in a large amount of free text with limited machine understandability. Therefore there is a need to develop automatic approaches to extract structured PGx-specific drug-gene relationships from unstructured free text literature. In this study, we have developed a conditional relationship extraction approach to extract PGx-specific drug-gene pairs from 20 million MEDLINE abstracts using known drug-gene pairs as prior knowledge. We have demonstrated that the conditional drug-gene relationship extraction approach significantly improves the precision and F1 measure compared to the unconditioned approach (precision: 0.345 vs. 0.11; recall: 0.481 vs. 1.00; F1: 0.402 vs. 0.201). In this study, a method based on co-occurrence is used as the underlying relationship extraction method for its simplicity. It can be replaced by or combined with more advanced methods such as machine learning or natural language processing approaches to further improve the performance of the drug-gene relationship extraction from free text. Our method is not limited to extracting a drug-gene relationship; it can be generalized to extract other types of relationships when related background knowledge bases exist. |Computational Biology/*methods [MESH] |Data Mining/*methods [MESH] |Drug Discovery/*methods [MESH] |Humans [MESH] |MEDLINE [MESH]A knowledge-driven conditional approach to extract pharmacogenomics sp(epmc).pdf DeepDyve Pubget Overpricing