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10.12659/MSM.895543 http://scihub22266oqcxt.onion/10.12659/MSM.895543 C4588667!4588667 !26408630     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26408630 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Med+Sci+Monit 2015 ; 21 (ä): 2886-92 Nephropedia Template TP {{tp|p=26408630 |t=2015. Renal Protective Effect of Probucol in Rats with Contrast-Induced Nephropathy and its Underlying Mechanism |pdf=|usr=}}{{26408630 }} gab.com Text Renal Protective Effect of Probucol in Rats with Contrast-Induced Nephropathy and its Underlying Mechanism JO: Med Sci Monit http://www.kidney.de/pget.php?&tw=1&pmid=26408630 #FOAvip BACKGROUND: Contrast-induced nephropathy (CIN) refers to acute renal damage that occurs after the use of contrast agents. This study investigated the renal protective effect of probucol in a rat model of contrast-induced nephropathy and the mechanism of its effect. MATERIAL AND METHODS: Twenty-eight Wistar rats were randomly divided into the control group, model group, N-acetylcysteine(NAC) group, and probucol group. We used a rat model of iopromide-induced CIN. One day prior to modeling, the rats received gavage. At 24 h after the modeling, blood biochemistry and urine protein were assessed. Malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in renal tissue. Kidney sections were created for histopathological examination. RESULTS: The model group of rats showed significantly elevated levels of blood creatinine, urea nitrogen, 24-h urine protein, histopathological scores, and parameters of oxidative stress (P<0.05). Both the NAC and probucol groups demonstrated significantly lower Scr, BUN, and urine protein levels compared to the model group (P<0.05), with no significant difference between these 2 groups. The NAC group and the probucol group had significantly lower MDA and higher SOD than the model group at 24 h after modeling (P<0.05). The 8-OHdG-positive tubule of the probucol group and NAC group were significantly lower than those of the model group (p=0.046, P=0.0008), with significant difference between these 2 groups (P=0.024). CONCLUSIONS: Probucol can effectively reduce kidney damage caused by contrast agent. The underlying mechanism may be that probucol accelerates the recovery of renal function and renal pathology by reducing local renal oxidative stress. Twit Text FOAVip Renal Protective Effect of Probucol in Rats with Contrast-Induced Nephropathy and its Underlying Mechanism ????Med Sci Monit http://www.kidney.de/pget.php?&tw=1&pmid=26408630 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26408630 #FOAvip English Wikipedia <ref>{{Cite pmid|26408630 }}</ref> Renal Protective Effect of Probucol in Rats with Contrast-Induced Nephropathy and its Underlying Mechanism #MMPMID26408630 Wang N ; Wei RB ; Li QP ; Yang X ; Li P ; Huang MJ ; Wang R ; Cai GY ; Chen XM Med Sci Monit 2015[Sep]; 21 (ä): 2886-92 PMID26408630 show ga BACKGROUND: Contrast-induced nephropathy (CIN) refers to acute renal damage that occurs after the use of contrast agents. This study investigated the renal protective effect of probucol in a rat model of contrast-induced nephropathy and the mechanism of its effect. MATERIAL AND METHODS: Twenty-eight Wistar rats were randomly divided into the control group, model group, N-acetylcysteine(NAC) group, and probucol group. We used a rat model of iopromide-induced CIN. One day prior to modeling, the rats received gavage. At 24 h after the modeling, blood biochemistry and urine protein were assessed. Malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in renal tissue. Kidney sections were created for histopathological examination. RESULTS: The model group of rats showed significantly elevated levels of blood creatinine, urea nitrogen, 24-h urine protein, histopathological scores, and parameters of oxidative stress (P<0.05). Both the NAC and probucol groups demonstrated significantly lower Scr, BUN, and urine protein levels compared to the model group (P<0.05), with no significant difference between these 2 groups. The NAC group and the probucol group had significantly lower MDA and higher SOD than the model group at 24 h after modeling (P<0.05). The 8-OHdG-positive tubule of the probucol group and NAC group were significantly lower than those of the model group (p=0.046, P=0.0008), with significant difference between these 2 groups (P=0.024). CONCLUSIONS: Probucol can effectively reduce kidney damage caused by contrast agent. The underlying mechanism may be that probucol accelerates the recovery of renal function and renal pathology by reducing local renal oxidative stress. |8-Hydroxy-2'-Deoxyguanosine [MESH] |Acetylcysteine/chemistry [MESH] |Animals [MESH] |Antioxidants/chemistry [MESH] |Contrast Media/*adverse effects [MESH] |Creatinine/blood [MESH] |Deoxyguanosine/analogs & derivatives/chemistry [MESH] |Disease Models, Animal [MESH] |Immunohistochemistry [MESH] |Kidney Diseases/*chemically induced [MESH] |Kidney/metabolism [MESH] |Male [MESH] |Malondialdehyde/chemistry/metabolism [MESH] |Nitrogen/urine [MESH] |Oxidative Stress [MESH] |Probucol/*chemistry [MESH] |Rats [MESH] |Rats, Wistar [MESH]Renal Protective Effect of Probucol in Rats with Contrast-Induced Neph(epmc).pdf DeepDyve Pubget Overpricing