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10.1097/CAD.0000000000000283 http://scihub22266oqcxt.onion/10.1097/CAD.0000000000000283 C4588602!4588602 !26302210     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26302210 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Anticancer+Drugs 2015 ; 26 (10 ): 1026-33 Nephropedia Template TP {{tp|p=26302210 |t=2015. Para-toluenesulfonamide induces tongue squamous cell carcinoma cell death through disturbing lysosomal stability |pdf=|usr=}}{{26302210 }} gab.com Text Para-toluenesulfonamide induces tongue squamous cell carcinoma cell death through disturbing lysosomal stability JO: Anticancer Drugs http://www.kidney.de/pget.php?&tw=1&pmid=26302210 #FOAvip Para-toluenesulfonamide (PTS) has been implicated with anticancer effects against a variety of tumors. In the present study, we investigated the inhibitory effects of PTS on tongue squamous cell carcinoma (Tca-8113) and explored the lysosomal and mitochondrial changes after PTS treatment in vitro. High-performance liquid chromatography showed that PTS selectively accumulated in Tca-8113 cells with a relatively low concentration in normal fibroblasts. Next, the effects of PTS on cell viability, invasion, and cell death were determined. PTS significantly inhibited Tca-8113 cells' viability and invasive ability with increased cancer cell death. Flow cytometric analysis and the lactate dehydrogenase release assay showed that PTS induced cancer cell death by activating apoptosis and necrosis simultaneously. Morphological changes, such as cellular shrinkage, nuclear condensation as well as formation of apoptotic body and secondary lysosomes, were observed, indicating that PTS might induce cell death through disturbing lysosomal stability. Lysosomal integrity assay and western blot showed that PTS increased lysosomal membrane permeabilization associated with activation of lysosomal cathepsin B. Finally, PTS was shown to inhibit ATP biosynthesis and induce the release of mitochondrial cytochrome c. Therefore, our findings provide a novel insight into the use of PTS in cancer therapy. Twit Text FOAVip Para-toluenesulfonamide induces tongue squamous cell carcinoma cell death through disturbing lysosomal stability ????Anticancer Drugs http://www.kidney.de/pget.php?&tw=1&pmid=26302210 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26302210 #FOAvip English Wikipedia <ref>{{Cite pmid|26302210 }}</ref> Para-toluenesulfonamide induces tongue squamous cell carcinoma cell death through disturbing lysosomal stability #MMPMID26302210 Liu Z ; Liang C ; Zhang Z ; Pan J ; Xia H ; Zhong N ; Li L Anticancer Drugs 2015[Nov]; 26 (10 ): 1026-33 PMID26302210 show ga Para-toluenesulfonamide (PTS) has been implicated with anticancer effects against a variety of tumors. In the present study, we investigated the inhibitory effects of PTS on tongue squamous cell carcinoma (Tca-8113) and explored the lysosomal and mitochondrial changes after PTS treatment in vitro. High-performance liquid chromatography showed that PTS selectively accumulated in Tca-8113 cells with a relatively low concentration in normal fibroblasts. Next, the effects of PTS on cell viability, invasion, and cell death were determined. PTS significantly inhibited Tca-8113 cells' viability and invasive ability with increased cancer cell death. Flow cytometric analysis and the lactate dehydrogenase release assay showed that PTS induced cancer cell death by activating apoptosis and necrosis simultaneously. Morphological changes, such as cellular shrinkage, nuclear condensation as well as formation of apoptotic body and secondary lysosomes, were observed, indicating that PTS might induce cell death through disturbing lysosomal stability. Lysosomal integrity assay and western blot showed that PTS increased lysosomal membrane permeabilization associated with activation of lysosomal cathepsin B. Finally, PTS was shown to inhibit ATP biosynthesis and induce the release of mitochondrial cytochrome c. Therefore, our findings provide a novel insight into the use of PTS in cancer therapy. |Adenosine Triphosphate/biosynthesis [MESH] |Antineoplastic Agents/*pharmacology [MESH] |Apoptosis/drug effects [MESH] |Carcinoma, Squamous Cell/*drug therapy [MESH] |Cell Line, Tumor/drug effects [MESH] |Humans [MESH] |Lysosomes/*drug effects/ultrastructure [MESH] |Mitochondria/drug effects/metabolism [MESH] |Necrosis [MESH] |Sulfonamides/*pharmacology [MESH] |Toluene/*analogs & derivatives/pharmacology [MESH]Para-toluenesulfonamide induces tongue squamous cell carcinoma cell de(epmc).pdf DeepDyve Pubget Overpricing