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2015 ; 25
(5
): 269-73
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Clinical significance of urinary liver-type fatty acid binding protein at various
stages of nephropathy
#MMPMID26628791
Viswanathan V
; Sivakumar S
; Sekar V
; Umapathy D
; Kumpatla S
Indian J Nephrol
2015[Sep]; 25
(5
): 269-73
PMID26628791
show ga
This cross-sectional study was to evaluate the levels of urinary liver-type fatty
acid binding protein (u-LFABP pg/mg urine creatinine ratio) at different stages
of diabetic nephropathy and to see its correlation with other clinical parameters
in South Indian patients with type 2 diabetes mellitus (T2DM). A total of 65 (M:
F; 42:23) T2DM subjects were divided into three groups, and were compared with 13
(M: F; 3:10) nondiabetic controls. The study groups were as follows:
normoalbuminuric (n = 22), microalbuminuric (n = 22) and macroalbuminuric (n =
21). Estimated glomerular filtration rate (eGFR) was calculated using Cockcroft
and Gault formula. u-LFABP levels in spot urine samples were measured with a
solid phase enzyme linked immunosorbent assay. This study showed that u-LFABP
levels were undetectable in healthy controls and was very low in the
normoalbuminuric subjects. Elevated levels of u-LFABP are evident from the
microalbuminuric stage indicating tubular damage. The levels of u-LFABP increased
gradually with declining renal function. Geometric mean (95% confidence interval)
for normoalbuminuria was 0.65 (0.47-0.97), microalbuminuria was 0.99 (0.55-1.97)
and macroalbuminuria was 5.16 (1.8-14.5), (P = 0.005). In conclusion, u-LFABP
levels were elevated in patients with reduced eGFR and showed a positive
correlation with systolic blood pressure and protein to creatinine ratio in the
total study subjects.