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10.1172/JCI80012 http://scihub22266oqcxt.onion/10.1172/JCI80012 C4588295!4588295!26325034     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2015 ; 125 (9): 3377-83 Nephropedia Template TP {{tp|p=26325034|t=2015. Cytotoxic T lymphocyte antigen-4 and immune checkpoint blockade |pdf=|usr=}}{{26325034}} gab.com Text Cytotoxic T lymphocyte antigen-4 and immune checkpoint blockade JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=26325034 #FOAvip The relationship between cancer and the immune system is complex and provides unique therapeutic opportunities. Cytotoxic T lymphocyte antigen-4 (CTLA-4) is a regulatory molecule that suppresses T cell effector function following initial activation by costimulatory signals. Fully human monoclonal antibodies targeting CTLA-4 have been shown to increase T cell function and antitumor responses in patients with advanced metastatic melanoma. Responses observed with such immune checkpoint therapy can follow a different pattern from that seen with cytotoxic chemotherapy or targeted therapy and may continue after therapy is discontinued. In addition, the toxicities that are associated with anti?CTLA-4 therapy may differ from those of conventional therapies and consist of inflammatory events in parts of the body that do not contain cancerous cells. Early recognition of these inflammatory events and intervention is important, and the identification of predictive biomarkers continues to be an unfulfilled need in the field of immunotherapy. Combinatorial approaches with targeted therapies, radiation therapy, chemotherapy, or other immune checkpoint agonists/antagonists have the potential to increase the efficacy of CTLA-4 blockade. Twit Text FOAVip Cytotoxic T lymphocyte antigen-4 and immune checkpoint blockade ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=26325034 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26325034 #FOAvip English Wikipedia <ref>{{Cite pmid|26325034}}</ref> Cytotoxic T lymphocyte antigen-4 and immune checkpoint blockade #MMPMID26325034 Buchbinder E; Hodi FS J Clin Invest 2015[Sep]; 125 (9): 3377-83 PMID26325034show ga The relationship between cancer and the immune system is complex and provides unique therapeutic opportunities. Cytotoxic T lymphocyte antigen-4 (CTLA-4) is a regulatory molecule that suppresses T cell effector function following initial activation by costimulatory signals. Fully human monoclonal antibodies targeting CTLA-4 have been shown to increase T cell function and antitumor responses in patients with advanced metastatic melanoma. Responses observed with such immune checkpoint therapy can follow a different pattern from that seen with cytotoxic chemotherapy or targeted therapy and may continue after therapy is discontinued. In addition, the toxicities that are associated with anti?CTLA-4 therapy may differ from those of conventional therapies and consist of inflammatory events in parts of the body that do not contain cancerous cells. Early recognition of these inflammatory events and intervention is important, and the identification of predictive biomarkers continues to be an unfulfilled need in the field of immunotherapy. Combinatorial approaches with targeted therapies, radiation therapy, chemotherapy, or other immune checkpoint agonists/antagonists have the potential to increase the efficacy of CTLA-4 blockade. äCytotoxic T lymphocyte antigen-4 and immune checkpoint blockade (epmc).pdf DeepDyve Pubget Overpricing