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10.3390/pharmaceutics7030175

http://scihub22266oqcxt.onion/10.3390/pharmaceutics7030175
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C4588193!4588193!26247958
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suck abstract from ncbi


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pmid26247958      Pharmaceutics 2015 ; 7 (3): 175-87
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  • Neurosurgical Techniques for Disruption of the Blood?Brain Barrier for Glioblastoma Treatment #MMPMID26247958
  • Rodriguez A; Tatter SB; Debinski W
  • Pharmaceutics 2015[Sep]; 7 (3): 175-87 PMID26247958show ga
  • The blood?brain barrier remains a main hurdle to drug delivery to the brain. The prognosis of glioblastoma remains grim despite current multimodal medical management. We review neurosurgical technologies that disrupt the blood?brain barrier (BBB). We will review superselective intra-arterial mannitol infusion, focused ultrasound, laser interstitial thermotherapy, and non-thermal irreversible electroporation (NTIRE). These technologies can lead to transient BBB and blood?brain tumor barrier disruption and allow for the potential of more effective local drug delivery. Animal studies and preliminary clinical trials show promise for achieving this goal.
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