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10.1097/WNN.0000000000000071 http://scihub22266oqcxt.onion/10.1097/WNN.0000000000000071 C4588069!4588069!26413742     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cogn+Behav+Neurol 2015 ; 28 (3): 144-52 Nephropedia Template TP {{tp|p=26413742|t=2015. Alzheimer Lesions in the Autopsied Brains of People 30 to 50 Years of Age |pdf=|usr=}}{{26413742}} gab.com Text Alzheimer Lesions in the Autopsied Brains of People 30 to 50 Years of Age JO: Cogn Behav Neurol http://www.kidney.de/pget.php?&tw=1&pmid=26413742 #FOAvip Objective: To test the hypothesis that asymptomatic Alzheimer disease lesions may appear before 50 years of age. Background: Alzheimer disease has an asymptomatic stage during which people are cognitively intact despite having substantial pathologic changes in the brain. While this asymptomatic stage is common in older people, how early in life it may develop has been unknown. Methods: We microscopically examined the postmortem brains of 154 people aged 30-39 years (n = 59) and 40-50 years (n = 95) for specific Alzheimer lesions: beta-amyloid plaques, neurofibrillary tangles, and tau-positive neurites. We genotyped DNA samples for the apolipoprotein E gene (APOE). Results: We found beta-amyloid lesions in 13 brains, all of them from people aged 40 to 49 with no history of dementia. These plaques were of the diffuse type only and appeared throughout the neocortex. Among these 13 brains, 5 had very subtle tau lesions in the entorhinal cortex and/or hippocampus. All individuals with beta-amyloid deposits carried 1 or 2 APOE4 alleles. Among the individuals aged 40 to 50 with genotype APOE3/4, 10 (36%) had beta-amyloid deposits but 18 (64%) had none. Conclusions: Our study demonstrates that beta-amyloid deposits in the cerebral cortex appear as early as 40 years of age in APOE4 carriers, suggesting that these lesions may constitute a very early stage of Alzheimer disease. Future preventive and therapeutic measures for this disease may have to be stratified by risk factors like APOE genotype and target people in their 40s or even earlier. Twit Text FOAVip Alzheimer Lesions in the Autopsied Brains of People 30 to 50 Years of Age ????Cogn Behav Neurol http://www.kidney.de/pget.php?&tw=1&pmid=26413742 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26413742 #FOAvip English Wikipedia <ref>{{Cite pmid|26413742}}</ref> Alzheimer Lesions in the Autopsied Brains of People 30 to 50 Years of Age #MMPMID26413742 Pletnikova O; Rudow GL; Hyde TM; Kleinman JE; Ali SZ; Bharadwaj R; Gangadeen S; Crain BJ; Fowler DR; Rubio AI; Troncoso JC Cogn Behav Neurol 2015[Sep]; 28 (3): 144-52 PMID26413742show ga Objective: To test the hypothesis that asymptomatic Alzheimer disease lesions may appear before 50 years of age. Background: Alzheimer disease has an asymptomatic stage during which people are cognitively intact despite having substantial pathologic changes in the brain. While this asymptomatic stage is common in older people, how early in life it may develop has been unknown. Methods: We microscopically examined the postmortem brains of 154 people aged 30-39 years (n = 59) and 40-50 years (n = 95) for specific Alzheimer lesions: beta-amyloid plaques, neurofibrillary tangles, and tau-positive neurites. We genotyped DNA samples for the apolipoprotein E gene (APOE). Results: We found beta-amyloid lesions in 13 brains, all of them from people aged 40 to 49 with no history of dementia. These plaques were of the diffuse type only and appeared throughout the neocortex. Among these 13 brains, 5 had very subtle tau lesions in the entorhinal cortex and/or hippocampus. All individuals with beta-amyloid deposits carried 1 or 2 APOE4 alleles. Among the individuals aged 40 to 50 with genotype APOE3/4, 10 (36%) had beta-amyloid deposits but 18 (64%) had none. Conclusions: Our study demonstrates that beta-amyloid deposits in the cerebral cortex appear as early as 40 years of age in APOE4 carriers, suggesting that these lesions may constitute a very early stage of Alzheimer disease. Future preventive and therapeutic measures for this disease may have to be stratified by risk factors like APOE genotype and target people in their 40s or even earlier. äAlzheimer Lesions in the Autopsied Brains of People 30 to 50 Years of (epmc).pdf DeepDyve Pubget Overpricing