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10.1186/s12958-015-0108-y http://scihub22266oqcxt.onion/10.1186/s12958-015-0108-y C4587772!4587772!26416573     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Reprod+Biol+Endocrinol 2015 ; 13 (ä): ä Nephropedia Template TP {{tp|p=26416573|t=2015. Pappa2 deletion in mice affects male but not female fertility |pdf=|usr=}}{{26416573}} gab.com Text Pappa2 deletion in mice affects male but not female fertility JO: Reprod Biol Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=26416573 #FOAvip Background: Recent studies have found associations between the gene encoding pregnancy associated plasma protein-A2 (PAPP-A2), a protease of insulin-like growth factor binding protein -5 (IGFBP-5), and measures of female reproductive performance in cattle. The purpose of the present study was to test the effects of Pappa2 deletion on reproduction in mice. Findings: We measured the fertility and offspring growth of Pappa2 deletion females, and also performed reciprocal matings (i.e., deletion males mated to control females) to control for the effects of offspring genotype. Ovarian and testicular IGFBP-5 levels were measured by Western blotting. As expected, deletion of Pappa2 increased ovarian IGFBP-5 levels. However, Pappa2 deletion in females had no effect on the interval between pairing and the birth of the first litter, the interval between the births of the first and second litters, or litter size. Offspring weight was lower in the offspring of Pappa2 deletion females, but effects of similar magnitude were observed in the offspring of Pappa2 deletion males, suggesting that the effects were due to heterozygosity for the deletion in the offspring. Pappa2 deletion in males had no effect on litter size or the interval between pairing and the birth of the first litter. However, the interval between the births of the first and second litters was significantly longer in deletion males. Conclusions: Pappa2 deletion had no effect on female reproductive performance. In contrast, Pappa2 deletion had subtle effects on male fertility, although the underlying mechanism remains to be elucidated. Twit Text FOAVip Pappa2 deletion in mice affects male but not female fertility ????Reprod Biol Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=26416573 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26416573 #FOAvip English Wikipedia <ref>{{Cite pmid|26416573}}</ref> Pappa2 deletion in mice affects male but not female fertility #MMPMID26416573 Christians JK; King AY; Rogowska MD; Hessels SM Reprod Biol Endocrinol 2015[]; 13 (ä): ä PMID26416573show ga Background: Recent studies have found associations between the gene encoding pregnancy associated plasma protein-A2 (PAPP-A2), a protease of insulin-like growth factor binding protein -5 (IGFBP-5), and measures of female reproductive performance in cattle. The purpose of the present study was to test the effects of Pappa2 deletion on reproduction in mice. Findings: We measured the fertility and offspring growth of Pappa2 deletion females, and also performed reciprocal matings (i.e., deletion males mated to control females) to control for the effects of offspring genotype. Ovarian and testicular IGFBP-5 levels were measured by Western blotting. As expected, deletion of Pappa2 increased ovarian IGFBP-5 levels. However, Pappa2 deletion in females had no effect on the interval between pairing and the birth of the first litter, the interval between the births of the first and second litters, or litter size. Offspring weight was lower in the offspring of Pappa2 deletion females, but effects of similar magnitude were observed in the offspring of Pappa2 deletion males, suggesting that the effects were due to heterozygosity for the deletion in the offspring. Pappa2 deletion in males had no effect on litter size or the interval between pairing and the birth of the first litter. However, the interval between the births of the first and second litters was significantly longer in deletion males. Conclusions: Pappa2 deletion had no effect on female reproductive performance. In contrast, Pappa2 deletion had subtle effects on male fertility, although the underlying mechanism remains to be elucidated. äPappa2 deletion in mice affects male but not female fertility (epmc).pdf DeepDyve Pubget Overpricing