Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23692590
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Eur+J+Neurosci
2013 ; 38
(1
): 2125-38
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Atypical cortical representation of peripheral visual space in children with an
autism spectrum disorder
#MMPMID23692590
Frey HP
; Molholm S
; Lalor EC
; Russo NN
; Foxe JJ
Eur J Neurosci
2013[Jul]; 38
(1
): 2125-38
PMID23692590
show ga
A key feature of early visual cortical regions is that they contain discretely
organized retinotopic maps. Titration of these maps must occur through
experience, and the fidelity of their spatial tuning will depend on the
consistency and accuracy of the eye movement system. Anomalies in fixation
patterns and the ballistics of eye movements are well documented in autism
spectrum disorder (ASD), with off-center fixations a hallmark of the phenotype.
We hypothesized that these atypicalities might affect the development of
visuo-spatial maps and specifically that peripheral inputs might receive altered
processing in ASD. Using high-density recordings of visual evoked potentials
(VEPs) and a novel system-identification approach known as VESPA (visual evoked
spread spectrum analysis), we assessed sensory responses to centrally and
peripherally presented stimuli. Additionally, input luminance was varied to bias
responsiveness to the magnocellular system, given previous suggestions of
magnocellular-specific deficits in ASD. Participants were 22 ASD children
(7-17 years of age) and 31 age- and performance-IQ-matched neurotypical controls.
Both VEP and VESPA responses to central presentations were indistinguishable
between groups. In contrast, peripheral presentations resulted in significantly
greater early VEP and VESPA amplitudes in the ASD cohort. We found no evidence
that anomalous enhancement was restricted to magnocellular-biased responses. The
extent of peripheral response enhancement was related to the severity of
stereotyped behaviors and restricted interests, cardinal symptoms of ASD. The
current results point to differential visuo-spatial cortical mapping in ASD,
shedding light on the consequences of peculiarities in gaze and stereotyped
visual behaviors often reported by clinicians working with this population.
|*Evoked Potentials, Visual
[MESH]
|*Visual Perception
[MESH]
|Adolescent
[MESH]
|Case-Control Studies
[MESH]
|Child
[MESH]
|Child Development Disorders, Pervasive/diagnosis/*physiopathology
[MESH]