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10.1007/s12035-014-8925-0 http://scihub22266oqcxt.onion/10.1007/s12035-014-8925-0 C4587357!4587357!25339580     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Neurobiol 2015 ; 52 (3): 1315-29 Nephropedia Template TP {{tp|p=25339580|t=2015. The role of Atonal factors in mechanosensory cell specification and function |pdf=|usr=}}{{25339580}} gab.com Text The role of Atonal factors in mechanosensory cell specification and function JO: Mol Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=25339580 #FOAvip atonal genes are basic helix-loop-helix transcription factors that were first identified as regulating the formation of mechanoreceptors and photoreceptors in Drosophila. Isolation of vertebrate homologs of atonal genes has shown these transcription factors to play diverse roles in the development of neurons and their progenitors, gut epithelial cells and mechanosensory cells in the inner ear and skin. In this article, we review the molecular function and regulation of atonal genes and their targets, with particular emphasis on the function of Atoh1 in the development, survival and function of hair cells of the inner ear. We discuss cell-extrinsic signals that induce Atoh1 expression, and the transcriptional networks that regulate its expression during development. Finally, we discuss recent work showing how identification of Atoh1 target genes in the cerebellum, spinal cord and gut can be used to propose candidate Atoh1 targets in tissues such as the inner ear where cell numbers and biochemical material are limiting. Twit Text FOAVip The role of Atonal factors in mechanosensory cell specification and function ????Mol Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=25339580 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25339580 #FOAvip English Wikipedia <ref>{{Cite pmid|25339580}}</ref> The role of Atonal factors in mechanosensory cell specification and function #MMPMID25339580 Cai T; Groves AK Mol Neurobiol 2015[Dec]; 52 (3): 1315-29 PMID25339580show ga atonal genes are basic helix-loop-helix transcription factors that were first identified as regulating the formation of mechanoreceptors and photoreceptors in Drosophila. Isolation of vertebrate homologs of atonal genes has shown these transcription factors to play diverse roles in the development of neurons and their progenitors, gut epithelial cells and mechanosensory cells in the inner ear and skin. In this article, we review the molecular function and regulation of atonal genes and their targets, with particular emphasis on the function of Atoh1 in the development, survival and function of hair cells of the inner ear. We discuss cell-extrinsic signals that induce Atoh1 expression, and the transcriptional networks that regulate its expression during development. Finally, we discuss recent work showing how identification of Atoh1 target genes in the cerebellum, spinal cord and gut can be used to propose candidate Atoh1 targets in tissues such as the inner ear where cell numbers and biochemical material are limiting. äThe role of Atonal factors in mechanosensory cell specification and fu(epmc).pdf DeepDyve Pubget Overpricing