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10.1073/pnas.1507387112 http://scihub22266oqcxt.onion/10.1073/pnas.1507387112 C4586854!4586854!26351669     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (38): 11929-34 Nephropedia Template TP {{tp|p=26351669|t=2015. TNF-??stimulated fibroblasts secrete lumican to promote fibrocyte differentiation |pdf=|usr=}}{{26351669}} gab.com Text TNF- stimulated fibroblasts secrete lumican to promote fibrocyte differentiation JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26351669 #FOAvip Fibrosis is involved in 30?45% of deaths in the U.S. The disease may involve a runaway positive feedback loop between fibroblasts and monocyte-derived fibrocytes. The signals from fibrocytes to fibroblasts include inflammatory cytokines such as TNF-?, but the signals from TNF-?-stimulated fibroblasts to fibrocytes are unknown. We find that one of these signals is the protein lumican, and show that lumican levels are increased in fibrotic lesions. The identification of lumican as a signal in fibrotic tissues that promotes fibrocyte differentiation represents a major advance in our understanding of the regulation of the innate immune system, supports the positive feedback loop model of fibrosis, and indicates that lumican-inhibiting drugs may be beneficial in regulating fibrosis. Twit Text FOAVip TNF- stimulated fibroblasts secrete lumican to promote fibrocyte differentiation ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26351669 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26351669 #FOAvip English Wikipedia <ref>{{Cite pmid|26351669}}</ref> TNF-??stimulated fibroblasts secrete lumican to promote fibrocyte differentiation #MMPMID26351669 Pilling D; Vakil V; Cox N; Gomer RH Proc Natl Acad Sci U S A 2015[Sep]; 112 (38): 11929-34 PMID26351669show ga Fibrosis is involved in 30?45% of deaths in the U.S. The disease may involve a runaway positive feedback loop between fibroblasts and monocyte-derived fibrocytes. The signals from fibrocytes to fibroblasts include inflammatory cytokines such as TNF-?, but the signals from TNF-?-stimulated fibroblasts to fibrocytes are unknown. We find that one of these signals is the protein lumican, and show that lumican levels are increased in fibrotic lesions. The identification of lumican as a signal in fibrotic tissues that promotes fibrocyte differentiation represents a major advance in our understanding of the regulation of the innate immune system, supports the positive feedback loop model of fibrosis, and indicates that lumican-inhibiting drugs may be beneficial in regulating fibrosis. äTNF-??stimulated fibroblasts secrete lumican to promote fibrocyte diff(epmc).pdf DeepDyve Pubget Overpricing