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10.1073/pnas.1511270112 http://scihub22266oqcxt.onion/10.1073/pnas.1511270112 C4586852!4586852!26324941     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (38): E5281-9 Nephropedia Template TP {{tp|p=26324941|t=2015. Complexity of the human memory B-cell compartment is determined by the versatility of clonal diversification in germinal centers |pdf=|usr=}}{{26324941}} gab.com Text Complexity of the human memory B-cell compartment is determined by the versatility of clonal diversification in germinal centers JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26324941 #FOAvip The complexity of the human memory B-lymphocyte compartment is a key component to depict and understand adaptive immunity. Despite numerous prior investigations, the generation of certain memory B-cell subsets, the dependency on T-cell help, and the composition, size, and diversity of clonal expansions are either poorly understood or debated. Here we provide an extensive and tightly controlled immunoglobulin heavy chain variable (IGHV) gene repertoire analysis of four main human memory B-cell subpopulations, revealing that an ordered diversification in germinal centers determines a highly versatile memory B-cell compartment in humans with surprisingly many very large B-cell clones. Twit Text FOAVip Complexity of the human memory B-cell compartment is determined by the versatility of clonal diversification in germinal centers ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26324941 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26324941 #FOAvip English Wikipedia <ref>{{Cite pmid|26324941}}</ref> Complexity of the human memory B-cell compartment is determined by the versatility of clonal diversification in germinal centers #MMPMID26324941 Budeus B; Schweigle de Reynoso S; Przekopowitz M; Hoffmann D; Seifert M; Küppers R Proc Natl Acad Sci U S A 2015[Sep]; 112 (38): E5281-9 PMID26324941show ga The complexity of the human memory B-lymphocyte compartment is a key component to depict and understand adaptive immunity. Despite numerous prior investigations, the generation of certain memory B-cell subsets, the dependency on T-cell help, and the composition, size, and diversity of clonal expansions are either poorly understood or debated. Here we provide an extensive and tightly controlled immunoglobulin heavy chain variable (IGHV) gene repertoire analysis of four main human memory B-cell subpopulations, revealing that an ordered diversification in germinal centers determines a highly versatile memory B-cell compartment in humans with surprisingly many very large B-cell clones. äComplexity of the human memory B-cell compartment is determined by the(epmc).pdf DeepDyve Pubget Overpricing