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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (38): E5318-26 Nephropedia Template TP
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Provirophages in the Bigelowiella genome bear testimony to past encounters with giant viruses #MMPMID26305943
Blanc G; Gallot-Lavallée L; Maumus F
Proc Natl Acad Sci U S A 2015[Sep]; 112 (38): E5318-26 PMID26305943show ga
Virophages are viruses that hijack the replication machinery of giant viruses for their own replication. Virophages negatively impact giant virus replication and improve the survival chances of eukaryotic cells infected by giant viruses. In this study, we identified segments of the Bigelowiella natans genome that originate from virophages and giant viruses, revealing genomic footprints of battles between these viral entities that occurred in this unicellular alga. Interestingly, genes of virophage origin are transcribed, suggesting that they are functional. We hypothesize that virophage integration may be beneficial to both the virophage and B. natans by increasing the chances for the virophage to coinfect the cell with a giant virus prey and by defending the host cell against fatal giant virus infections.