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2015 ; 7
(3
): 1863-84
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The Potential Role of Hedgehog Signaling in the Luminal/Basal Phenotype of Breast
Epithelia and in Breast Cancer Invasion and Metastasis
#MMPMID26389956
Flemban A
; Qualtrough D
Cancers (Basel)
2015[Sep]; 7
(3
): 1863-84
PMID26389956
show ga
The epithelium of the lactiferous ducts in the breast is comprised of luminal
epithelial cells and underlying basal myoepithelial cells. The regulation of cell
fate and transit of cells between these two cell types remains poorly understood.
This relationship becomes of greater importance when studying the subtypes of
epithelial breast carcinoma, which are categorized according to their expression
of luminal or basal markers. The epithelial mesenchymal transition (EMT) is a
pivotal event in tumor invasion. It is important to understand mechanisms that
regulate this process, which bears relation to the normal dynamic of
epithelial/basal phenotype regulation in the mammary gland. Understanding this
process could provide answers for the regulation of EMT in breast cancer, and
thereby identify potential targets for therapy. Evidence points towards a role
for hedgehog signaling in breast tissue homeostasis and also in mammary
neoplasia. This review examines our current understanding of role of the
hedgehog-signaling (Hh) pathway in breast epithelial cells both during breast
development and homeostasis and to assess the potential misappropriation of Hh
signals in breast neoplasia, cancer stem cells and tumor metastasis via EMT.
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