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10.3390/cancers7030860 http://scihub22266oqcxt.onion/10.3390/cancers7030860 C4586793!4586793!26404379     free     free     free       Cancers+(Basel) 2015 ; 7 (3): 1758-84 Nephropedia Template TP {{tp|p=26404379|t=2015. Targeting RTK Signaling Pathways in Cancer |pdf=|usr=}}{{26404379}} gab.com Text Targeting RTK Signaling Pathways in Cancer JO: Cancers (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=26404379 #FOAvip The RAS/MAP kinase and the RAS/PI3K/AKT pathways play a key role in the regulation of proliferation, differentiation and survival. The induction of these pathways depends on Receptor Tyrosine Kinases (RTKs) that are activated upon ligand binding. In cancer, constitutive and aberrant activations of components of those pathways result in increased proliferation, survival and metastasis. For instance, mutations affecting RTKs, Ras, B-Raf, PI3K and AKT are common in perpetuating the malignancy of several types of cancers and from different tissue origins. Therefore, these signaling pathways became prime targets for cancer therapy. This review aims to provide an overview about the most frequently encountered mutations, the pathogenesis that results from such mutations and the known therapeutic strategies developed to counteract their aberrant functions. Twit Text FOAVip Targeting RTK Signaling Pathways in Cancer ????Cancers (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=26404379 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26404379 #FOAvip English Wikipedia <ref>{{Cite pmid|26404379}}</ref> Targeting RTK Signaling Pathways in Cancer #MMPMID26404379 Regad T Cancers (Basel) 2015[Sep]; 7 (3): 1758-84 PMID26404379show ga The RAS/MAP kinase and the RAS/PI3K/AKT pathways play a key role in the regulation of proliferation, differentiation and survival. The induction of these pathways depends on Receptor Tyrosine Kinases (RTKs) that are activated upon ligand binding. In cancer, constitutive and aberrant activations of components of those pathways result in increased proliferation, survival and metastasis. For instance, mutations affecting RTKs, Ras, B-Raf, PI3K and AKT are common in perpetuating the malignancy of several types of cancers and from different tissue origins. Therefore, these signaling pathways became prime targets for cancer therapy. This review aims to provide an overview about the most frequently encountered mutations, the pathogenesis that results from such mutations and the known therapeutic strategies developed to counteract their aberrant functions. äTargeting RTK Signaling Pathways in Cancer (epmc).pdf DeepDyve Pubget Overpricing