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2015 ; 7
(3
): 1178-90
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and
Future Directions
#MMPMID26147335
Berman AT
; James SS
; Rengan R
Cancers (Basel)
2015[Jul]; 7
(3
): 1178-90
PMID26147335
show ga
Lung cancer is the leading cancer cause of death in the United States.
Radiotherapy is an essential component of the definitive treatment of early-stage
and locally-advanced lung cancer, and the palliative treatment of metastatic lung
cancer. Proton beam therapy (PBT), through its characteristic Bragg peak, has the
potential to decrease the toxicity of radiotherapy, and, subsequently improve the
therapeutic ratio. Herein, we provide a primer on the physics of proton beam
therapy for lung cancer, present the existing data in early-stage and
locally-advanced non-small cell lung cancer (NSCLC), as well as in special
situations such as re-irradiation and post-operative radiation therapy. We then
present the technical challenges, such as anatomic changes and motion management,
and future directions for PBT in lung cancer, including pencil beam scanning.