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10.1083/jcb.201504047

http://scihub22266oqcxt.onion/10.1083/jcb.201504047
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C4586742!4586742!26416963
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suck abstract from ncbi


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pmid26416963      J+Cell+Biol 2015 ; 210 (7): 1101-15
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  • PDK2-mediated alternative splicing switches Bnip3 from cell death to cell survival #MMPMID26416963
  • Gang H; Dhingra R; Lin J; Hai Y; Aviv Y; Margulets V; Hamedani M; Thanasupawat T; Leygue E; Klonisch T; Davie JR; Kirshenbaum LA
  • J Cell Biol 2015[Sep]; 210 (7): 1101-15 PMID26416963show ga
  • In hypoxia, the survival property of cancer cells mediated by the glycolytic enzyme PDK2 is obligatorily linked to alternative splicing and generation of a novel isoform of death gene Bnip3, which suppresses mitochondrial injury and promotes survival.
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