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10.1083/jcb.201501059 http://scihub22266oqcxt.onion/10.1083/jcb.201501059 C4586740!4586740 !26416964     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26416964 &cmd=llinks): Failed to open stream: HTTP request failed! 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RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4 |pdf=|usr=}}{{26416964 }} gab.com Text RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4 JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26416964 #FOAvip Autophagy is a key degradative pathway coordinated by external cues, including starvation, oxidative stress, or pathogen detection. Rare are the molecules known to contribute mechanistically to the regulation of autophagy and expressed specifically in particular environmental contexts or in distinct cell types. Here, we unravel the role of RUN and FYVE domain-containing protein 4 (RUFY4) as a positive molecular regulator of macroautophagy in primary dendritic cells (DCs). We show that exposure to interleukin-4 (IL-4) during DC differentiation enhances autophagy flux through mTORC1 regulation and RUFY4 induction, which in turn actively promote LC3 degradation, Syntaxin 17-positive autophagosome formation, and lysosome tethering. Enhanced autophagy boosts endogenous antigen presentation by MHC II and allows host control of Brucella abortus replication in IL-4-treated DCs and in RUFY4-expressing cells. RUFY4 is therefore the first molecule characterized to date that promotes autophagy and influences endosome dynamics in a subset of immune cells. Twit Text FOAVip RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4 ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26416964 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26416964 #FOAvip English Wikipedia <ref>{{Cite pmid|26416964 }}</ref> RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4 #MMPMID26416964 Terawaki S ; Camosseto V ; Prete F ; Wenger T ; Papadopoulos A ; Rondeau C ; Combes A ; Rodriguez Rodrigues C ; Vu Manh TP ; Fallet M ; English L ; Santamaria R ; Soares AR ; Weil T ; Hammad H ; Desjardins M ; Gorvel JP ; Santos MA ; Gatti E ; Pierre P J Cell Biol 2015[Sep]; 210 (7 ): 1133-52 PMID26416964 show ga Autophagy is a key degradative pathway coordinated by external cues, including starvation, oxidative stress, or pathogen detection. Rare are the molecules known to contribute mechanistically to the regulation of autophagy and expressed specifically in particular environmental contexts or in distinct cell types. Here, we unravel the role of RUN and FYVE domain-containing protein 4 (RUFY4) as a positive molecular regulator of macroautophagy in primary dendritic cells (DCs). We show that exposure to interleukin-4 (IL-4) during DC differentiation enhances autophagy flux through mTORC1 regulation and RUFY4 induction, which in turn actively promote LC3 degradation, Syntaxin 17-positive autophagosome formation, and lysosome tethering. Enhanced autophagy boosts endogenous antigen presentation by MHC II and allows host control of Brucella abortus replication in IL-4-treated DCs and in RUFY4-expressing cells. RUFY4 is therefore the first molecule characterized to date that promotes autophagy and influences endosome dynamics in a subset of immune cells. |Animals [MESH] |Autophagy/genetics/*immunology [MESH] |Brucella abortus/immunology [MESH] |Dendritic Cells/cytology/*immunology [MESH] |Interleukin-4/genetics/*immunology [MESH] |Intracellular Signaling Peptides and Proteins/genetics/*immunology [MESH] |Lysosomes/genetics/*immunology [MESH] |Mechanistic Target of Rapamycin Complex 1 [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Microtubule-Associated Proteins/genetics/immunology [MESH] |Multiprotein Complexes/genetics/immunology [MESH] |Qa-SNARE Proteins/genetics/immunology [MESH]RUN and FYVE domain-containing protein 4 enhances autophagy and lysoso(epmc).pdf DeepDyve Pubget Overpricing