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2015 ; 12
(9
): 11196-208
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English Wikipedia
Effect of Sodium Selenite on Pathological Changes and Renal Functions in Broilers
Fed a Diet Containing Aflatoxin B?
#MMPMID26371027
Liang N
; Wang F
; Peng X
; Fang J
; Cui H
; Chen Z
; Lai W
; Zhou Y
; Geng Y
Int J Environ Res Public Health
2015[Sep]; 12
(9
): 11196-208
PMID26371027
show ga
To evaluate the renal toxicity of dietary aflatoxin B? (AFB?) and ameliorating
effects of added dietary sodium selenite in broiler, renal histopathological
changes, ultrastructural changes, and renal function parameters were monitored at
7, 14, and 21 days of age. Two hundred one-day-old healthy male Avian broilers
were divided into four groups, namely control group, AFB? group (0.3 mg/kg AFB?),
+Se group (0.4 mg/kg Se), and AFB?+Se group (0.3 mg/kg AFB?+0.4 mg/kg Se).
Compared with that of the control group, the relative weight of kidney was
increased in the AFB? group. There were no significant differences between the
AFB?+Se group and the control group. By histopathological observation, the renal
epithelia were swelling and necrosis at 7 and 21 days of age. Ultrastructurally,
the lipid droplets and expanded endoplasmic reticulum appeared in the plasma of
epithelia cells in the AFB? group. Enlarged mitochondria with degenerated cristae
were observed in the +Se group. Compared with the control group, the contents of
serum creatinine and serum uric acid in the AFB? group were increased, while the
activity of renal Na?-K? ATPase was decreased. When 0.4 mg/kg selenium was added
into the diet containing 0.3 mg/kg AFB?, there were no obvious histological
changes in the AFB?+Se group, and the contents of the serum creatinine and serum
uric acid contents and the activity of renal Na?-K? ATPase were close to those in
the control group. In conclusion, sodium selenite exhibited protective effects on
AFB?-induced kidney toxicity in broilers.
|Aflatoxin B1/*toxicity
[MESH]
|Animals
[MESH]
|Body Weight
[MESH]
|Chickens
[MESH]
|Creatinine/blood
[MESH]
|Dietary Supplements
[MESH]
|Kidney Diseases/blood/pathology/*prevention & control
[MESH]