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10.3390/ijerph120910739 http://scihub22266oqcxt.onion/10.3390/ijerph120910739 C4586640!4586640!26340635     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Environ+Res+Public+Health 2015 ; 12 (9): 10739-54 Nephropedia Template TP {{tp|p=26340635|t=2015. Blocking the Wnt/?-Catenin Pathway by Lentivirus-Mediated Short Hairpin RNA Targeting ?-Catenin Gene Suppresses Silica-Induced Lung Fibrosis in Mice |pdf=|usr=}}{{26340635}} gab.com Text Blocking the Wnt/ -Catenin Pathway by Lentivirus-Mediated Short Hairpin RNA Targeting -Catenin Gene Suppresses Silica-Induced Lung Fibrosis in Mice JO: Int J Environ Res Public Health http://www.kidney.de/pget.php?&tw=1&pmid=26340635 #FOAvip Silicosis is a form of occupational lung disease caused by inhalation of crystalline silica dust. While the pathogenesis of silicosis is not clearly understood, the Wnt/?-catenin signaling pathway is thought to play a major role in lung fibrosis. To explore the role of Wnt/?-catenin pathway in silicosis, we blocked Wnt/?-catenin pathway both in silica-treated MLE-12 cells (a mouse pulmonary epithelial cell line) and in a mouse silicosis model by using a lentiviral vector expressing a short hairpin RNA silencing ?-catenin (Lv-sh?-catenin). In vitro, Lv-sh?-catenin significantly decreased the expression of ?-catenin, MMP2 and MMP9, and secretion of TGF-?1. In vivo, intratracheal treatment with Lv-sh?-catenin significantly reduced expression of ?-catenin in the lung and levels of TGF-?1 in bronchoalveolar lavage fluid, and notably attenuated pulmonary fibrosis as evidenced by hydroxyproline content and collagen I\III synthesis in silica-administered mice. These results indicate that blockade of the Wnt/?-catenin pathway can prevent the development of silica-induced lung fibrosis. Thus Wnt/?-catenin pathway may be a target in prevention and treatment of silicosis. Twit Text FOAVip Blocking the Wnt/ -Catenin Pathway by Lentivirus-Mediated Short Hairpin RNA Targeting -Catenin Gene Suppresses Silica-Induced Lung Fibrosis in Mice ????Int J Environ Res Public Health http://www.kidney.de/pget.php?&tw=1&pmid=26340635 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26340635 #FOAvip English Wikipedia <ref>{{Cite pmid|26340635}}</ref> Blocking the Wnt/?-Catenin Pathway by Lentivirus-Mediated Short Hairpin RNA Targeting ?-Catenin Gene Suppresses Silica-Induced Lung Fibrosis in Mice #MMPMID26340635 Wang X; Dai W; Wang Y; Gu Q; Yang D; Zhang M Int J Environ Res Public Health 2015[Sep]; 12 (9): 10739-54 PMID26340635show ga Silicosis is a form of occupational lung disease caused by inhalation of crystalline silica dust. While the pathogenesis of silicosis is not clearly understood, the Wnt/?-catenin signaling pathway is thought to play a major role in lung fibrosis. To explore the role of Wnt/?-catenin pathway in silicosis, we blocked Wnt/?-catenin pathway both in silica-treated MLE-12 cells (a mouse pulmonary epithelial cell line) and in a mouse silicosis model by using a lentiviral vector expressing a short hairpin RNA silencing ?-catenin (Lv-sh?-catenin). In vitro, Lv-sh?-catenin significantly decreased the expression of ?-catenin, MMP2 and MMP9, and secretion of TGF-?1. In vivo, intratracheal treatment with Lv-sh?-catenin significantly reduced expression of ?-catenin in the lung and levels of TGF-?1 in bronchoalveolar lavage fluid, and notably attenuated pulmonary fibrosis as evidenced by hydroxyproline content and collagen I\III synthesis in silica-administered mice. These results indicate that blockade of the Wnt/?-catenin pathway can prevent the development of silica-induced lung fibrosis. Thus Wnt/?-catenin pathway may be a target in prevention and treatment of silicosis. äBlocking the Wnt/?-Catenin Pathway by Lentivirus-Mediated Short Hairpi(epmc).pdf DeepDyve Pubget Overpricing