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10.3390/ijerph120910739 http://scihub22266oqcxt.onion/10.3390/ijerph120910739 C4586640!4586640 !26340635     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26340635 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Environ+Res+Public+Health 2015 ; 12 (9 ): 10739-54 Nephropedia Template TP {{tp|p=26340635 |t=2015. Blocking the Wnt/?-Catenin Pathway by Lentivirus-Mediated Short Hairpin RNA Targeting ?-Catenin Gene Suppresses Silica-Induced Lung Fibrosis in Mice |pdf=|usr=}}{{26340635 }} gab.com Text Blocking the Wnt/ -Catenin Pathway by Lentivirus-Mediated Short Hairpin RNA Targeting -Catenin Gene Suppresses Silica-Induced Lung Fibrosis in Mice JO: Int J Environ Res Public Health http://www.kidney.de/pget.php?&tw=1&pmid=26340635 #FOAvip Silicosis is a form of occupational lung disease caused by inhalation of crystalline silica dust. While the pathogenesis of silicosis is not clearly understood, the Wnt/?-catenin signaling pathway is thought to play a major role in lung fibrosis. To explore the role of Wnt/?-catenin pathway in silicosis, we blocked Wnt/?-catenin pathway both in silica-treated MLE-12 cells (a mouse pulmonary epithelial cell line) and in a mouse silicosis model by using a lentiviral vector expressing a short hairpin RNA silencing ?-catenin (Lv-sh?-catenin). In vitro, Lv-sh?-catenin significantly decreased the expression of ?-catenin, MMP2 and MMP9, and secretion of TGF-?1. In vivo, intratracheal treatment with Lv-sh?-catenin significantly reduced expression of ?-catenin in the lung and levels of TGF-?1 in bronchoalveolar lavage fluid, and notably attenuated pulmonary fibrosis as evidenced by hydroxyproline content and collagen I\III synthesis in silica-administered mice. These results indicate that blockade of the Wnt/?-catenin pathway can prevent the development of silica-induced lung fibrosis. Thus Wnt/?-catenin pathway may be a target in prevention and treatment of silicosis. Twit Text FOAVip Blocking the Wnt/ -Catenin Pathway by Lentivirus-Mediated Short Hairpin RNA Targeting -Catenin Gene Suppresses Silica-Induced Lung Fibrosis in Mice ????Int J Environ Res Public Health http://www.kidney.de/pget.php?&tw=1&pmid=26340635 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26340635 #FOAvip English Wikipedia <ref>{{Cite pmid|26340635 }}</ref> Blocking the Wnt/?-Catenin Pathway by Lentivirus-Mediated Short Hairpin RNA Targeting ?-Catenin Gene Suppresses Silica-Induced Lung Fibrosis in Mice #MMPMID26340635 Wang X ; Dai W ; Wang Y ; Gu Q ; Yang D ; Zhang M Int J Environ Res Public Health 2015[Sep]; 12 (9 ): 10739-54 PMID26340635 show ga Silicosis is a form of occupational lung disease caused by inhalation of crystalline silica dust. While the pathogenesis of silicosis is not clearly understood, the Wnt/?-catenin signaling pathway is thought to play a major role in lung fibrosis. To explore the role of Wnt/?-catenin pathway in silicosis, we blocked Wnt/?-catenin pathway both in silica-treated MLE-12 cells (a mouse pulmonary epithelial cell line) and in a mouse silicosis model by using a lentiviral vector expressing a short hairpin RNA silencing ?-catenin (Lv-sh?-catenin). In vitro, Lv-sh?-catenin significantly decreased the expression of ?-catenin, MMP2 and MMP9, and secretion of TGF-?1. In vivo, intratracheal treatment with Lv-sh?-catenin significantly reduced expression of ?-catenin in the lung and levels of TGF-?1 in bronchoalveolar lavage fluid, and notably attenuated pulmonary fibrosis as evidenced by hydroxyproline content and collagen I\III synthesis in silica-administered mice. These results indicate that blockade of the Wnt/?-catenin pathway can prevent the development of silica-induced lung fibrosis. Thus Wnt/?-catenin pathway may be a target in prevention and treatment of silicosis. |*Disease Models, Animal [MESH] |Animals [MESH] |Bronchoalveolar Lavage Fluid [MESH] |Cell Line [MESH] |Gene Silencing/physiology [MESH] |Genetic Vectors [MESH] |Lentivirus/*genetics [MESH] |Matrix Metalloproteinase 2/metabolism [MESH] |Matrix Metalloproteinase 9/metabolism [MESH] |Mice [MESH] |Pulmonary Fibrosis/metabolism/*prevention & control [MESH] |RNA, Small Interfering/*genetics [MESH] |Silicon Dioxide/toxicity [MESH] |Silicosis/metabolism/*prevention & control [MESH] |Transforming Growth Factor beta1/metabolism [MESH] |Wnt Signaling Pathway/*physiology [MESH]Blocking the Wnt/?-Catenin Pathway by Lentivirus-Mediated Short Hairpi(epmc).pdf DeepDyve Pubget Overpricing