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2015 ; 7
(9
): 7256-70
Nephropedia Template TP
gab.com Text
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English Wikipedia
The Role of Immunonutrients in the Prevention of Necrotizing Enterocolitis in
Preterm Very Low Birth Weight Infants
#MMPMID26343718
Zhou P
; Li Y
; Ma LY
; Lin HC
Nutrients
2015[Aug]; 7
(9
): 7256-70
PMID26343718
show ga
Necrotizing enterocolitis (NEC) is a critical intestinal emergency condition,
which mainly occurs in preterm very low birth weight (PVLBW) infants. Despite
remarkable advances in the care of PVLBW infants, with considerable improvement
of the survival rate in recent decades, the incidence of NEC and NEC-related
mortality have not declined accordingly. The fast progression from nonspecific
signs to extensive necrosis also makes primary prevention the first priority.
Recently, increasing evidence has indicated the important role of several
nutrients in primary prevention of NEC. Therefore, the aim of this review is to
summarize some potential immunomodulatory nutrients in the prevention of NEC,
including bovine colostrum, probiotics, prebiotics (e.g., human milk
oligosaccharides), long chain polyunsaturated fatty acids, and amino acids
(glutamine, cysteine and N-acetylcysteine, l-arginine and l-citrulline). Based on
current research evidence, probiotics are the most documented effective method to
prevent NEC, while others still require further investigation in animal studies
and clinical randomized controlled trials.