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10.1038/srep14548 http://scihub22266oqcxt.onion/10.1038/srep14548 C4586487!4586487!26416554     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26416554|t=2015. PTBP1 and PTBP2 impaired autoregulation of SRSF3 in cancer cells |pdf=|usr=}}{{26416554}} gab.com Text PTBP1 and PTBP2 impaired autoregulation of SRSF3 in cancer cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26416554 #FOAvip Splicing factors are key players in the regulation of alternative splicing of pre-mRNAs. Overexpression of splicing factors, including SRSF3, has been strongly linked with oncogenesis. However, the mechanisms behind their overexpression remain largely unclear. Autoregulation is a common mechanism to maintain relative stable expression levels of splicing factors in cells. SRSF3 regulates its own expression by enhancing the inclusion of an alternative exon 4 with an in-frame stop codon. We found that the inclusion of SRSF3 exon 4 is impaired in oral squamous cell carcinoma (OSCC) cells. PTBP1 and PTBP2 bind to an exonic splicing suppressor in exon 4 and inhibit its inclusion, which results in overexpression of full length functional SRSF3. Overexpression of SRSF3, in turn, promotes PTBP2 expression. Our results suggest a novel mechanism for the overexpression of oncogenic splicing factor via impairing autoregulation in cancer cells. Twit Text FOAVip PTBP1 and PTBP2 impaired autoregulation of SRSF3 in cancer cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26416554 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26416554 #FOAvip English Wikipedia <ref>{{Cite pmid|26416554}}</ref> PTBP1 and PTBP2 impaired autoregulation of SRSF3 in cancer cells #MMPMID26416554 Guo J; Jia J; Jia R Sci Rep 2015[]; 5 (ä): ä PMID26416554show ga Splicing factors are key players in the regulation of alternative splicing of pre-mRNAs. Overexpression of splicing factors, including SRSF3, has been strongly linked with oncogenesis. However, the mechanisms behind their overexpression remain largely unclear. Autoregulation is a common mechanism to maintain relative stable expression levels of splicing factors in cells. SRSF3 regulates its own expression by enhancing the inclusion of an alternative exon 4 with an in-frame stop codon. We found that the inclusion of SRSF3 exon 4 is impaired in oral squamous cell carcinoma (OSCC) cells. PTBP1 and PTBP2 bind to an exonic splicing suppressor in exon 4 and inhibit its inclusion, which results in overexpression of full length functional SRSF3. Overexpression of SRSF3, in turn, promotes PTBP2 expression. Our results suggest a novel mechanism for the overexpression of oncogenic splicing factor via impairing autoregulation in cancer cells. äPTBP1 and PTBP2 impaired autoregulation of SRSF3 in cancer cells (epmc).pdf DeepDyve Pubget Overpricing