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10.1161/HYPERTENSIONAHA.110.168120 http://scihub22266oqcxt.onion/10.1161/HYPERTENSIONAHA.110.168120 C4586117!4586117!21482957     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hypertension 2011 ; 58 (1): 85-92 Nephropedia Template TP {{tp|p=21482957|t=2011. CONTRARY EFFECTS OF THE RTK INHIBITOR VANDETANIB ON CONSTITUTIVE AND FLOW-STIMULATED NITRIC OXIDE ELABORATION IN HUMANS |pdf=|usr=}}{{21482957}} gab.com Text CONTRARY EFFECTS OF THE RTK INHIBITOR VANDETANIB ON CONSTITUTIVE AND FLOW-STIMULATED NITRIC OXIDE ELABORATION IN HUMANS JO: Hypertension http://www.kidney.de/pget.php?&tw=1&pmid=21482957 #FOAvip Vascular endothelial growth factor regulates neoplastic angiogenesis through production of endothelium-derived nitric oxide. We performed a prospective evaluation of vascular function during treatment with vandetanib, a vascular endothelial growth receptor 2 and 3 receptor tyrosine kinase inhibitor, to determine the effects of vascular endothelial growth receptor signal interruption on endothelial function in humans. Seventeen patients with stage IV breast cancer received dose escalated vandetanib in combination with low-dose oral chemotherapy. We measured blood pressure, systemic nitrate/nitrite levels, and brachial artery vascular function. In vitro analyses of cultured endothelial cells were performed to determine the effect of vandetanib on nitric oxide production, akt473 phosphorylation, and endothelial nitric oxide synthase protein content and membrane localization. Vandetanib treatment for 6 weeks significantly increased blood pressure, decreased resting brachial artery diameter, and decreased plasma systemic nitrate/nitrite levels compared to baseline. Flow-mediated vasodilation was preserved, and no change was noted in nitroglycerin-mediated vasodilation. In vitro, endothelial cell nitrite levels and akt473 phosphorylation were reduced, vascular endothelial growth receptor 2 levels did not change, but endothelial nitric oxide synthase membrane concentration doubled. Vandetanib reduces constitutive nitric oxide production and increases blood pressure, yet flow-stimulated nitric oxide bioavailability was preserved. Changes in vascular function with tyrosine kinase inhibition are complex and require further study in humans. Twit Text FOAVip CONTRARY EFFECTS OF THE RTK INHIBITOR VANDETANIB ON CONSTITUTIVE AND FLOW-STIMULATED NITRIC OXIDE ELABORATION IN HUMANS ????Hypertension http://www.kidney.de/pget.php?&tw=1&pmid=21482957 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21482957 #FOAvip English Wikipedia <ref>{{Cite pmid|21482957}}</ref> CONTRARY EFFECTS OF THE RTK INHIBITOR VANDETANIB ON CONSTITUTIVE AND FLOW-STIMULATED NITRIC OXIDE ELABORATION IN HUMANS #MMPMID21482957 Mayer EL; Dallabrida SM; Rupnick MA; Redline WM; Hannagan K; Ismail NS; Burstein HJ; Beckman JA Hypertension 2011[Jul]; 58 (1): 85-92 PMID21482957show ga Vascular endothelial growth factor regulates neoplastic angiogenesis through production of endothelium-derived nitric oxide. We performed a prospective evaluation of vascular function during treatment with vandetanib, a vascular endothelial growth receptor 2 and 3 receptor tyrosine kinase inhibitor, to determine the effects of vascular endothelial growth receptor signal interruption on endothelial function in humans. Seventeen patients with stage IV breast cancer received dose escalated vandetanib in combination with low-dose oral chemotherapy. We measured blood pressure, systemic nitrate/nitrite levels, and brachial artery vascular function. In vitro analyses of cultured endothelial cells were performed to determine the effect of vandetanib on nitric oxide production, akt473 phosphorylation, and endothelial nitric oxide synthase protein content and membrane localization. Vandetanib treatment for 6 weeks significantly increased blood pressure, decreased resting brachial artery diameter, and decreased plasma systemic nitrate/nitrite levels compared to baseline. Flow-mediated vasodilation was preserved, and no change was noted in nitroglycerin-mediated vasodilation. In vitro, endothelial cell nitrite levels and akt473 phosphorylation were reduced, vascular endothelial growth receptor 2 levels did not change, but endothelial nitric oxide synthase membrane concentration doubled. Vandetanib reduces constitutive nitric oxide production and increases blood pressure, yet flow-stimulated nitric oxide bioavailability was preserved. Changes in vascular function with tyrosine kinase inhibition are complex and require further study in humans. äCONTRARY EFFECTS OF THE RTK INHIBITOR VANDETANIB ON CONSTITUTIVE AND F(epmc).pdf DeepDyve Pubget Overpricing