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10.1097/MIB.0000000000000158 http://scihub22266oqcxt.onion/10.1097/MIB.0000000000000158 C4586112!4586112!25192497     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Inflamm+Bowel+Dis 2014 ; 20 (11): 1910-8 Nephropedia Template TP {{tp|p=25192497|t=2014. MicroRNA-346 Mediates Tumor Necrosis Factor-?-induced Down-Regulation of Gut Epithelial Vitamin D Receptor in Inflammatory Bowel Diseases |pdf=|usr=}}{{25192497}} gab.com Text MicroRNA-346 Mediates Tumor Necrosis Factor- -induced Down-Regulation of Gut Epithelial Vitamin D Receptor in Inflammatory Bowel Diseases JO: Inflamm Bowel Dis http://www.kidney.de/pget.php?&tw=1&pmid=25192497 #FOAvip Background: We recently reported that the gut epithelial vitamin D receptor (VDR) signaling inhibits colitis through inhibition of intestinal epithelial cell apoptosis, and the level of colonic epithelial VDR is markedly reduced in patients with inflammatory bowel diseases (IBD). VDR down-regulation promotes colitis, but the mechanism underlying VDR down-regulation in IBD is unknown. Methods: VDR expression was analyzed in colon cancer cells under pro-inflammatory cytokine treatment. VDR as a target of miR-346 was confirmed using colon cancer cell culture. The relationship among inflammation, miR-346 and VDR was assessed in human IBD biopsies and experimental colitis models. Results: We showed that TNF-? suppresses VDR expression while simultaneously up-regulating miR-346 in human colon cancer cells. Further studies demonstrated that miR-346 inhibits VDR by a specific target sequence in the 3? untranslated region of the human VDR transcript, and blockade of miR-346 with a hairpin inhibitor abrogates the ability of TNF-? to inhibit VDR, confirming that TNF-? down-regulates VDR by inducing miR-346. Consistently, in human IBD biopsies the reduction of epithelial VDR is associated with increased immune cell infiltration and elevation of TNF-? and miR-346. In an experimental model of colitis mucosal VDR expression is reduced over time with the progression of colitis, inversely correlated with the induction of TNF-? and miR-346 in the mucosa. Conclusion: These data suggest that during mucosal inflammation TNF-? induces miR-346, which down-regulates epithelial VDR. Mucosal VDR reduction in turn compromises the integrity of the mucosal epithelial barrier, further driving mucosal inflammation and colitis development. Twit Text FOAVip MicroRNA-346 Mediates Tumor Necrosis Factor- -induced Down-Regulation of Gut Epithelial Vitamin D Receptor in Inflammatory Bowel Diseases ????Inflamm Bowel Dis http://www.kidney.de/pget.php?&tw=1&pmid=25192497 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25192497 #FOAvip English Wikipedia <ref>{{Cite pmid|25192497}}</ref> MicroRNA-346 Mediates Tumor Necrosis Factor-?-induced Down-Regulation of Gut Epithelial Vitamin D Receptor in Inflammatory Bowel Diseases #MMPMID25192497 Chen Y; Du J; Zhang Z; Liu T; Shi Y; Ge X; Li YC Inflamm Bowel Dis 2014[Nov]; 20 (11): 1910-8 PMID25192497show ga Background: We recently reported that the gut epithelial vitamin D receptor (VDR) signaling inhibits colitis through inhibition of intestinal epithelial cell apoptosis, and the level of colonic epithelial VDR is markedly reduced in patients with inflammatory bowel diseases (IBD). VDR down-regulation promotes colitis, but the mechanism underlying VDR down-regulation in IBD is unknown. Methods: VDR expression was analyzed in colon cancer cells under pro-inflammatory cytokine treatment. VDR as a target of miR-346 was confirmed using colon cancer cell culture. The relationship among inflammation, miR-346 and VDR was assessed in human IBD biopsies and experimental colitis models. Results: We showed that TNF-? suppresses VDR expression while simultaneously up-regulating miR-346 in human colon cancer cells. Further studies demonstrated that miR-346 inhibits VDR by a specific target sequence in the 3? untranslated region of the human VDR transcript, and blockade of miR-346 with a hairpin inhibitor abrogates the ability of TNF-? to inhibit VDR, confirming that TNF-? down-regulates VDR by inducing miR-346. Consistently, in human IBD biopsies the reduction of epithelial VDR is associated with increased immune cell infiltration and elevation of TNF-? and miR-346. In an experimental model of colitis mucosal VDR expression is reduced over time with the progression of colitis, inversely correlated with the induction of TNF-? and miR-346 in the mucosa. Conclusion: These data suggest that during mucosal inflammation TNF-? induces miR-346, which down-regulates epithelial VDR. Mucosal VDR reduction in turn compromises the integrity of the mucosal epithelial barrier, further driving mucosal inflammation and colitis development. äMicroRNA-346 Mediates Tumor Necrosis Factor-?-induced Down-Regulation (epmc).pdf DeepDyve Pubget Overpricing