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10.1177/0748730415573167 http://scihub22266oqcxt.onion/10.1177/0748730415573167 C4586074!4586074 !25724980     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25724980 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Biol+Rhythms 2015 ; 30 (2 ): 155-60 Nephropedia Template TP {{tp|p=25724980 |t=2015. Circadian rhythmicity of active GSK3 isoforms modulates molecular clock gene rhythms in the suprachiasmatic nucleus |pdf=|usr=}}{{25724980 }} gab.com Text Circadian rhythmicity of active GSK3 isoforms modulates molecular clock gene rhythms in the suprachiasmatic nucleus JO: J Biol Rhythms http://www.kidney.de/pget.php?&tw=1&pmid=25724980 #FOAvip The suprachiasmatic nucleus (SCN) drives and synchronizes daily rhythms at the cellular level via transcriptional-translational feedback loops comprising clock genes such as Bmal1 and Period (Per). Glycogen synthase kinase 3 (GSK3), a serine/threonine kinase, phosphorylates at least 5 core clock proteins and shows diurnal variation in phosphorylation state (inactivation) of the GSK3? isoform. Whether phosphorylation of the other primary isoform (GSK3?) varies across the subjective day-night cycle is unknown. The purpose of this study was to determine if the endogenous rhythm of GSK3 (? and ?) phosphorylation is critical for rhythmic BMAL1 expression and normal amplitude and periodicity of the molecular clock in the SCN. Significant circadian rhythmicity of phosphorylated GSK3 (? and ?) was observed in the SCN from wild-type mice housed in constant darkness for 2 weeks. Importantly, chronic activation of both GSK3 isoforms impaired rhythmicity of the GSK3 target BMAL1. Furthermore, chronic pharmacological inhibition of GSK3 with 20 µM CHIR-99021 enhanced the amplitude and shortened the period of PER2::luciferase rhythms in organotypic SCN slice cultures. These results support the model that GSK3 activity status is regulated by the circadian clock and that GSK3 feeds back to regulate the molecular clock amplitude in the SCN. Twit Text FOAVip Circadian rhythmicity of active GSK3 isoforms modulates molecular clock gene rhythms in the suprachiasmatic nucleus ????J Biol Rhythms http://www.kidney.de/pget.php?&tw=1&pmid=25724980 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25724980 #FOAvip English Wikipedia <ref>{{Cite pmid|25724980 }}</ref> Circadian rhythmicity of active GSK3 isoforms modulates molecular clock gene rhythms in the suprachiasmatic nucleus #MMPMID25724980 Besing RC ; Paul JR ; Hablitz LM ; Rogers CO ; Johnson RL ; Young ME ; Gamble KL J Biol Rhythms 2015[Apr]; 30 (2 ): 155-60 PMID25724980 show ga The suprachiasmatic nucleus (SCN) drives and synchronizes daily rhythms at the cellular level via transcriptional-translational feedback loops comprising clock genes such as Bmal1 and Period (Per). Glycogen synthase kinase 3 (GSK3), a serine/threonine kinase, phosphorylates at least 5 core clock proteins and shows diurnal variation in phosphorylation state (inactivation) of the GSK3? isoform. Whether phosphorylation of the other primary isoform (GSK3?) varies across the subjective day-night cycle is unknown. The purpose of this study was to determine if the endogenous rhythm of GSK3 (? and ?) phosphorylation is critical for rhythmic BMAL1 expression and normal amplitude and periodicity of the molecular clock in the SCN. Significant circadian rhythmicity of phosphorylated GSK3 (? and ?) was observed in the SCN from wild-type mice housed in constant darkness for 2 weeks. Importantly, chronic activation of both GSK3 isoforms impaired rhythmicity of the GSK3 target BMAL1. Furthermore, chronic pharmacological inhibition of GSK3 with 20 µM CHIR-99021 enhanced the amplitude and shortened the period of PER2::luciferase rhythms in organotypic SCN slice cultures. These results support the model that GSK3 activity status is regulated by the circadian clock and that GSK3 feeds back to regulate the molecular clock amplitude in the SCN. |ARNTL Transcription Factors/genetics [MESH] |Animals [MESH] |CLOCK Proteins/metabolism [MESH] |Circadian Clocks [MESH] |Circadian Rhythm/*physiology [MESH] |Darkness [MESH] |Feedback, Physiological [MESH] |Glycogen Synthase Kinase 3 beta [MESH] |Glycogen Synthase Kinase 3/antagonists & inhibitors/*metabolism [MESH] |Mice [MESH] |Period Circadian Proteins/metabolism [MESH] |Pyridines/antagonists & inhibitors/pharmacology [MESH] |Pyrimidines/antagonists & inhibitors/pharmacology [MESH]Circadian rhythmicity of active GSK3 isoforms modulates molecular cloc(epmc).pdf DeepDyve Pubget Overpricing