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2015 ; 52
(3
): 1284-1296
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Crosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications
for the Treatment of Neurological Diseases
#MMPMID25330936
Wu H
; Chen S
; Ammar AB
; Xu J
; Wu Q
; Pan K
; Zhang J
; Hong Y
Mol Neurobiol
2015[Dec]; 52
(3
): 1284-1296
PMID25330936
show ga
Macroautophagy and chaperone-mediated autophagy (CMA) are two important subtypes
of autophagy that play a critical role in cellular quality control under
physiological and pathological conditions. Despite the marked differences between
these two autophagic pathways, macroautophagy and CMA are intimately connected
with each other during the autophagy-lysosomal degradation process, in
particular, in the setting of neurological illness. Macroautophagy serves as a
backup mechanism to removal of malfunctioning proteins (i.e., aberrant
?-synuclein) from the cytoplasm when CMA is compromised, and vice versa. The
molecular mechanisms underlying the conversation between macroautophagy and CMA
are being clarified. Herein, we survey current overviews concentrating on the
complex interactions between macroautophagy and CMA, and present therapeutic
potentials through utilization and manipulation of macroautophagy-CMA crosstalk
in the treatment of neurological diseases.