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10.1038/srep14478 http://scihub22266oqcxt.onion/10.1038/srep14478 C4585986!4585986 !26411375     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26411375 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 14478 Nephropedia Template TP {{tp|p=26411375 |t=2015. Expression of IL-37 contributes to the immunosuppressive property of human CD4+CD25+ regulatory T cells |pdf=|usr=}}{{26411375 }} gab.com Text Expression of IL-37 contributes to the immunosuppressive property of human CD4+CD25+ regulatory T cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26411375 #FOAvip Interleukin-37 (IL-37) possesses the function of down-regulate systemic and local inflammation. It is unknown whether IL-37 is expressed in human regulatory T cells (Tregs) and its role in modulating the immune response of Tregs. In the present study, cell surface molecules and secretory cytokines were analyzed in order to determine the function of IL-37 in regulating inhibitory effect of human CD4(+)CD25(+)Tregs. Meanwhile, the effects of IL-37 on T cell differentiation and proliferation as co-culture of CD4(+)CD25(+)Treg/CD4(+)CD25(-)T cell were also investigated. It was showed that IL-37 was expressed in cytoplasm of CD4(+)CD25(+)Tregs, and the levels of IL-37 were gradually elevated with the enhanced activity of CD4(+)CD25(+)Tregs. Secretory cytokines such as transforming growth factor (TGF)-? and interleukin (IL)-10, and expressions of cell surface molecules, including forkhead/winged helix transcription factor p3 (FOXP3) and cytotoxic T-lymphocyte associated antigen (CTLA)-4, were significantly decreased when IL-37 gene was silenced by siRNA. Furthermore, down-regulation of IL-37 expression in human CD4(+)CD25(+)Tregs obviously promoted proliferation of co-cultured T cell and differentiation, together with observably enhancement of IL-2 formation. These results demonstrated that IL-37 might manifest as a critical protein involving in immunosuppression of human CD4(+)CD25(+)Tregs. Twit Text FOAVip Expression of IL-37 contributes to the immunosuppressive property of human CD4+CD25+ regulatory T cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26411375 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26411375 #FOAvip English Wikipedia <ref>{{Cite pmid|26411375 }}</ref> Expression of IL-37 contributes to the immunosuppressive property of human CD4+CD25+ regulatory T cells #MMPMID26411375 Shuai X ; Wei-min L ; Tong YL ; Dong N ; Sheng ZY ; Yao YM Sci Rep 2015[Sep]; 5 (ä): 14478 PMID26411375 show ga Interleukin-37 (IL-37) possesses the function of down-regulate systemic and local inflammation. It is unknown whether IL-37 is expressed in human regulatory T cells (Tregs) and its role in modulating the immune response of Tregs. In the present study, cell surface molecules and secretory cytokines were analyzed in order to determine the function of IL-37 in regulating inhibitory effect of human CD4(+)CD25(+)Tregs. Meanwhile, the effects of IL-37 on T cell differentiation and proliferation as co-culture of CD4(+)CD25(+)Treg/CD4(+)CD25(-)T cell were also investigated. It was showed that IL-37 was expressed in cytoplasm of CD4(+)CD25(+)Tregs, and the levels of IL-37 were gradually elevated with the enhanced activity of CD4(+)CD25(+)Tregs. Secretory cytokines such as transforming growth factor (TGF)-? and interleukin (IL)-10, and expressions of cell surface molecules, including forkhead/winged helix transcription factor p3 (FOXP3) and cytotoxic T-lymphocyte associated antigen (CTLA)-4, were significantly decreased when IL-37 gene was silenced by siRNA. Furthermore, down-regulation of IL-37 expression in human CD4(+)CD25(+)Tregs obviously promoted proliferation of co-cultured T cell and differentiation, together with observably enhancement of IL-2 formation. These results demonstrated that IL-37 might manifest as a critical protein involving in immunosuppression of human CD4(+)CD25(+)Tregs. |*Gene Expression [MESH] |Biomarkers [MESH] |CTLA-4 Antigen/genetics/metabolism [MESH] |Cell Differentiation [MESH] |Coculture Techniques [MESH] |Forkhead Transcription Factors/genetics/metabolism [MESH] |Humans [MESH] |Immunomodulation/*genetics [MESH] |Interleukin-1/*genetics/metabolism [MESH] |Interleukin-10/metabolism [MESH] |Interleukin-2 Receptor alpha Subunit/metabolism [MESH] |Lymphocyte Activation/immunology [MESH] |Phenotype [MESH] |T-Lymphocyte Subsets/immunology/metabolism [MESH] |T-Lymphocytes, Regulatory/cytology/*immunology/*metabolism [MESH]Expression of IL-37 contributes to the immunosuppressive property of h(epmc).pdf DeepDyve Pubget Overpricing