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10.1038/srep13891 http://scihub22266oqcxt.onion/10.1038/srep13891 C4585899!4585899 !26403635     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26403635 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 13891 Nephropedia Template TP {{tp|p=26403635 |t=2015. High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations |pdf=|usr=}}{{26403635 }} gab.com Text High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26403635 #FOAvip Drug resistance in Plasmodium parasites is a constant threat. Novel therapeutics, especially new drug combinations, must be identified at a faster rate. In response to the urgent need for new antimalarial drug combinations we screened a large collection of approved and investigational drugs, tested 13,910 drug pairs, and identified many promising antimalarial drug combinations. The activity of known antimalarial drug regimens was confirmed and a myriad of new classes of positively interacting drug pairings were discovered. Network and clustering analyses reinforced established mechanistic relationships for known drug combinations and identified several novel mechanistic hypotheses. From eleven screens comprising >4,600 combinations per parasite strain (including duplicates) we further investigated interactions between approved antimalarials, calcium homeostasis modulators, and inhibitors of phosphatidylinositide 3-kinases (PI3K) and the mammalian target of rapamycin (mTOR). These studies highlight important targets and pathways and provide promising leads for clinically actionable antimalarial therapy. Twit Text FOAVip High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26403635 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26403635 #FOAvip English Wikipedia <ref>{{Cite pmid|26403635 }}</ref> High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations #MMPMID26403635 Mott BT ; Eastman RT ; Guha R ; Sherlach KS ; Siriwardana A ; Shinn P ; McKnight C ; Michael S ; Lacerda-Queiroz N ; Patel PR ; Khine P ; Sun H ; Kasbekar M ; Aghdam N ; Fontaine SD ; Liu D ; Mierzwa T ; Mathews-Griner LA ; Ferrer M ; Renslo AR ; Inglese J ; Yuan J ; Roepe PD ; Su XZ ; Thomas CJ Sci Rep 2015[Sep]; 5 (ä): 13891 PMID26403635 show ga Drug resistance in Plasmodium parasites is a constant threat. Novel therapeutics, especially new drug combinations, must be identified at a faster rate. In response to the urgent need for new antimalarial drug combinations we screened a large collection of approved and investigational drugs, tested 13,910 drug pairs, and identified many promising antimalarial drug combinations. The activity of known antimalarial drug regimens was confirmed and a myriad of new classes of positively interacting drug pairings were discovered. Network and clustering analyses reinforced established mechanistic relationships for known drug combinations and identified several novel mechanistic hypotheses. From eleven screens comprising >4,600 combinations per parasite strain (including duplicates) we further investigated interactions between approved antimalarials, calcium homeostasis modulators, and inhibitors of phosphatidylinositide 3-kinases (PI3K) and the mammalian target of rapamycin (mTOR). These studies highlight important targets and pathways and provide promising leads for clinically actionable antimalarial therapy. |*High-Throughput Screening Assays [MESH] |*Parasitic Sensitivity Tests [MESH] |Animals [MESH] |Antimalarials/*pharmacology [MESH] |Autophagy/drug effects [MESH] |Calcium/metabolism [MESH] |Cluster Analysis [MESH] |Disease Models, Animal [MESH] |Drug Antagonism [MESH] |Drug Synergism [MESH] |Drug Therapy, Combination [MESH] |Homeostasis/drug effects [MESH] |Humans [MESH] |Inhibitory Concentration 50 [MESH] |Malaria/drug therapy/parasitology [MESH] |Mice [MESH] |Mitochondria/drug effects/metabolism [MESH] |Oxidative Stress/drug effects [MESH] |Phagosomes/metabolism [MESH] |Phosphoinositide-3 Kinase Inhibitors [MESH]High-throughput matrix screening identifies synergistic and antagonist(epmc).pdf DeepDyve Pubget Overpricing