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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP
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One-year outcomes of conventional and accelerated collagen crosslinking in progressive keratoconus #MMPMID26404661
Chow VWS; Chan TCY; Yu M; Wong VWY; Jhanji V
Sci Rep 2015[]; 5 (ä): ä PMID26404661show ga
We compared one-year outcomes of conventional (3?mW/cm2, 365-nm ultraviolet-A light, 30?minutes) and accelerated (18?mW/cm2, 365-nm ultraviolet-A light, 5?minutes) collagen crosslinking (CXL) in patients with progressive keratoconus. Main outcome measures were change in keratometry, uncorrected visual acuity (UCVA), and best-corrected visual acuity (BCVA). Nineteen patients in each group completed 1-year follow-up. Preoperatively, there were no inter-group differences for age, keratometry, corneal thickness, and spherical equivalent (p?>?0.127). One year postoperatively, maximum and minimum keratometry were flattened by 1.6 diopters (p?0.023) and 2 diopters (p?0.047) respectively after conventional CXL, and, 0.47 diopters (p?=?0.471) and 0.19 diopters (p?=?0.120) respectively after accelerated CXL. Association analysis showed significant negative association between baseline maximum keratometry and change in maximum keratometry after accelerated CXL (p?=?0.002) but not after conventional CXL (p?=?0.110). Corneal thickness was reduced significantly in both groups (p?=?0.017). An improvement in UCVA (p?0.001) and BCVA (p?0.022) was noted in both groups along with a reduction in spherical equivalent postoperatively (p?0.026). There were no inter-group differences for any of the parameters postoperatively (p?>?0.184). Although no statistically significant differences were observed between both treatment modalities, a more effective topographic flattening was observed with conventional CXL as compared to accelerated CXL in this study.