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Entrainment of mouse peripheral circadian clocks to 24?h feeding/fasting cycles
under 24?h light/dark conditions
#MMPMID26395309
Hamaguchi Y
; Tahara Y
; Kuroda H
; Haraguchi A
; Shibata S
Sci Rep
2015[Sep]; 5
(?): 14207
PMID26395309
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The circadian clock system in peripheral tissues can endogenously oscillate and
is entrained by the light-dark and fasting-feeding cycles in mammals. Although
the system's range of entrainment to light-dark cycles with a non-24?h (<24?h)
interval has been studied, the range of entrainment to fasting-feeding cycles
with shorter periods (<24?h) has not been investigated in peripheral molecular
clocks. In the present study, we measured this range by monitoring the mouse
peripheral PER2::LUCIFERASE rhythm in vivo at different periods under each
feeding cycle (Tau (T)?=?15-24?h) under normal light-dark conditions. Peripheral
clocks could be entrained to the feeding cycle with T?=?22-24?h, but not to that
with T?=?15-21?h. Under the feeding cycle with T?=?15-18?h, the peripheral clocks
oscillated at near the 24-h period, suggesting that they were entrained to the
light-dark cycle. Thus, for the first time, we demonstrated the range of
entrainment to the non-24?h feeding cycle, and that the circadian range
(T?=?22-24?h) of feeding stimulus is necessary for peripheral molecular clock
entrainment under light-dark cycles.
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