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10.1038/srep14432 http://scihub22266oqcxt.onion/10.1038/srep14432 C4585774!4585774!26395317     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26395317|t=2015. Hyperactivation and in situ recruitment of inflammatory V?2 T cells contributes to disease pathogenesis in systemic lupus erythematosus |pdf=|usr=}}{{26395317}} gab.com Text Hyperactivation and in situ recruitment of inflammatory V 2 T cells contributes to disease pathogenesis in systemic lupus erythematosus JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26395317 #FOAvip In this study, we measured the proportion of peripheral V?2 T cells as well as the status and chemokine receptor expression profiles in SLE patients and healthy control (HC). In addition, V?2 T cell infiltration in the kidneys of patients with lupus nephritis was examined. The results showed that the percentage of peripheral V?2 T cells in new-onset SLE was decreased, and negatively correlated with the SLE Disease Activity Index score and the severity of proteinuria. These cells had a decreased apoptosis but an increased proliferation, and they showed increased accumulation in SLE kidneys. Moreover, IL-21 production and CD40L, CCR4, CCR7, CCR8, CXCR1 and CX3CR1 expression in V?2 T cells from SLE patients was significantly higher than from HC (p?<?0.05), and these factors were downregulated in association with the repopulation of peripheral V?2 T cells in patients who were in remission (p?<?0.05). In addition, anti-TCR V?2 antibodies activation significantly upregulated these chemokine receptors on V?2 T cells from HC, and this effect was blocked by inhibitors of PLC-?1, MAPK/Erk, and PI3K signaling pathways. Our findings demonstrate that the distribution and function status of V?2 T cells from SLE patients are abnormal, and these aberrations may contribute to disease pathogenesis. Twit Text FOAVip Hyperactivation and in situ recruitment of inflammatory V 2 T cells contributes to disease pathogenesis in systemic lupus erythematosus ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26395317 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26395317 #FOAvip English Wikipedia <ref>{{Cite pmid|26395317}}</ref> Hyperactivation and in situ recruitment of inflammatory V?2 T cells contributes to disease pathogenesis in systemic lupus erythematosus #MMPMID26395317 Yin S; Mao Y; Li X; Yue C; Zhou C; Huang L; Mo W; Liang D; Zhang J; He W; Zhang X Sci Rep 2015[]; 5 (ä): ä PMID26395317show ga In this study, we measured the proportion of peripheral V?2 T cells as well as the status and chemokine receptor expression profiles in SLE patients and healthy control (HC). In addition, V?2 T cell infiltration in the kidneys of patients with lupus nephritis was examined. The results showed that the percentage of peripheral V?2 T cells in new-onset SLE was decreased, and negatively correlated with the SLE Disease Activity Index score and the severity of proteinuria. These cells had a decreased apoptosis but an increased proliferation, and they showed increased accumulation in SLE kidneys. Moreover, IL-21 production and CD40L, CCR4, CCR7, CCR8, CXCR1 and CX3CR1 expression in V?2 T cells from SLE patients was significantly higher than from HC (p? äHyperactivation and in situ recruitment of inflammatory V?2 T cells co(epmc).pdf DeepDyve Pubget Overpricing