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10.1038/srep14432 http://scihub22266oqcxt.onion/10.1038/srep14432 C4585774!4585774 !26395317     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26395317 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 14432 Nephropedia Template TP {{tp|p=26395317 |t=2015. Hyperactivation and in situ recruitment of inflammatory V?2 T cells contributes to disease pathogenesis in systemic lupus erythematosus |pdf=|usr=}}{{26395317 }} gab.com Text Hyperactivation and in situ recruitment of inflammatory V 2 T cells contributes to disease pathogenesis in systemic lupus erythematosus JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26395317 #FOAvip In this study, we measured the proportion of peripheral V?2 T cells as well as the status and chemokine receptor expression profiles in SLE patients and healthy control (HC). In addition, V?2 T cell infiltration in the kidneys of patients with lupus nephritis was examined. The results showed that the percentage of peripheral V?2 T cells in new-onset SLE was decreased, and negatively correlated with the SLE Disease Activity Index score and the severity of proteinuria. These cells had a decreased apoptosis but an increased proliferation, and they showed increased accumulation in SLE kidneys. Moreover, IL-21 production and CD40L, CCR4, CCR7, CCR8, CXCR1 and CX3CR1 expression in V?2 T cells from SLE patients was significantly higher than from HC (p?<?0.05), and these factors were downregulated in association with the repopulation of peripheral V?2 T cells in patients who were in remission (p?<?0.05). In addition, anti-TCR V?2 antibodies activation significantly upregulated these chemokine receptors on V?2 T cells from HC, and this effect was blocked by inhibitors of PLC-?1, MAPK/Erk, and PI3K signaling pathways. Our findings demonstrate that the distribution and function status of V?2 T cells from SLE patients are abnormal, and these aberrations may contribute to disease pathogenesis. Twit Text FOAVip Hyperactivation and in situ recruitment of inflammatory V 2 T cells contributes to disease pathogenesis in systemic lupus erythematosus ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26395317 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26395317 #FOAvip English Wikipedia <ref>{{Cite pmid|26395317 }}</ref> Hyperactivation and in situ recruitment of inflammatory V?2 T cells contributes to disease pathogenesis in systemic lupus erythematosus #MMPMID26395317 Yin S ; Mao Y ; Li X ; Yue C ; Zhou C ; Huang L ; Mo W ; Liang D ; Zhang J ; He W ; Zhang X Sci Rep 2015[Sep]; 5 (ä): 14432 PMID26395317 show ga In this study, we measured the proportion of peripheral V?2 T cells as well as the status and chemokine receptor expression profiles in SLE patients and healthy control (HC). In addition, V?2 T cell infiltration in the kidneys of patients with lupus nephritis was examined. The results showed that the percentage of peripheral V?2 T cells in new-onset SLE was decreased, and negatively correlated with the SLE Disease Activity Index score and the severity of proteinuria. These cells had a decreased apoptosis but an increased proliferation, and they showed increased accumulation in SLE kidneys. Moreover, IL-21 production and CD40L, CCR4, CCR7, CCR8, CXCR1 and CX3CR1 expression in V?2 T cells from SLE patients was significantly higher than from HC (p? |Adolescent [MESH] |Adult [MESH] |Apoptosis/immunology [MESH] |CD40 Ligand/biosynthesis [MESH] |Cell Proliferation/genetics [MESH] |Cells, Cultured [MESH] |Chemokines/biosynthesis [MESH] |Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors [MESH] |Female [MESH] |Flow Cytometry [MESH] |Humans [MESH] |Interleukin-21 [MESH] |Interleukins/biosynthesis [MESH] |Kidney/immunology [MESH] |Lupus Nephritis/*immunology/*pathology [MESH] |Male [MESH] |Phosphoinositide-3 Kinase Inhibitors [MESH] |Phospholipase C gamma/antagonists & inhibitors [MESH] |Receptors, Antigen, T-Cell/*immunology [MESH] |Receptors, Chemokine/*biosynthesis [MESH] |T-Lymphocytes/*immunology [MESH]Hyperactivation and in situ recruitment of inflammatory V?2 T cells co(epmc).pdf DeepDyve Pubget Overpricing