Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26395517
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Continuous Reduction of Protein-Bound Uraemic Toxins with Improved Oxidative
Stress by Using the Oral Charcoal Adsorbent AST-120 in Haemodialysis Patients
#MMPMID26395517
Yamamoto S
; Kazama JJ
; Omori K
; Matsuo K
; Takahashi Y
; Kawamura K
; Matsuto T
; Watanabe H
; Maruyama T
; Narita I
Sci Rep
2015[Sep]; 5
(?): 14381
PMID26395517
show ga
Accumulation of protein-bound uraemic toxins (PBUTs) is one of the reasons for
the development of uraemia-related complications including cardiovascular
disease; however, conventional haemodialysis is limited in its ability to remove
PBUTs. We aimed to examine whether the oral charcoal adsorbent AST-120 has an
additive effect on PBUT removal in haemodialysis patients. During the 4-week
study, anuric patients undergoing haemodialysis received AST-120 (6?g/day) in the
last 2 weeks (n?=?10) or the first 2 weeks (n?=?10). Serum levels of total and
free PBUTs such as indoxyl sulfate, p-cresyl sulfate, and phenyl sulfate at the
pre- and postdialysis sessions were measured before and after AST-120 use and
after discontinuation. Levels of the oxidative stress markers oxidized albumin
and 8-isoprostane were also measured. AST-120 use induced dramatic reduction of
indoxyl sulfate (total, 45.7% [33.2-50.5%]; free, 70.4% [44.8-79.8%]), p-cresyl
sulfate (total, 31.1% [25.0-48.0%]; free, 63.5% [49.3-70.9%]), and phenyl sulfate
(free, 50.6% [32.3-71.2%]) levels; however, this effect disappeared after the
discontinuation of AST-120. AST-120 use also induced substantial reduction of the
oxidized albumin and 8-isoprostane levels. In conclusion, oral administration of
AST-120 had additive effects on the continuous reduction of some PBUTs in anuric
patients undergoing haemodialysis.
free
free
free
