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10.1038/srep14315 http://scihub22266oqcxt.onion/10.1038/srep14315 C4585760!4585760!26391888     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26391888|t=2015. Genome-wide homozygosity signature and risk of Hodgkin lymphoma |pdf=|usr=}}{{26391888}} gab.com Text Genome-wide homozygosity signature and risk of Hodgkin lymphoma JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26391888 #FOAvip Recent studies have reported that regions of homozygosity (ROH) in the genome are detectable in outbred populations and can be associated with an increased risk of malignancy. To examine whether homozygosity is associated with an increased risk of developing Hodgkin lymphoma (HL) we analysed 589 HL cases and 5,199 controls genotyped for 484,072 tag single nucleotide polymorphisms (SNPs). Across the genome the cumulative distribution of ROH was not significantly different between cases and controls. Seven ROH at 4q22.3, 4q32.2, 7p12.3?14.1, 7p22.2, 10p11.22?23, 19q13.12-2 and 19p13.2 were associated with HL risk at P?<?0.01. Intriguingly 4q22.3 harbours an ROH to which the nuclear factor NF-kappa-B p105 subunit (NFKB1) maps (P?=?0.002). The ROH at 19q13.12-2 has previously been implicated in B-cell precursor acute lymphoblastic leukaemia. Aside from these observations which require validation, it is unlikely that levels of measured homozygosity caused by autozygosity, uniparental isodisomy or hemizygosity play a major role in defining HL risk in predominantly outbred populations. Twit Text FOAVip Genome-wide homozygosity signature and risk of Hodgkin lymphoma ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26391888 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26391888 #FOAvip English Wikipedia <ref>{{Cite pmid|26391888}}</ref> Genome-wide homozygosity signature and risk of Hodgkin lymphoma #MMPMID26391888 Sud A; Cooke R; Swerdlow AJ; Houlston RS Sci Rep 2015[]; 5 (ä): ä PMID26391888show ga Recent studies have reported that regions of homozygosity (ROH) in the genome are detectable in outbred populations and can be associated with an increased risk of malignancy. To examine whether homozygosity is associated with an increased risk of developing Hodgkin lymphoma (HL) we analysed 589 HL cases and 5,199 controls genotyped for 484,072 tag single nucleotide polymorphisms (SNPs). Across the genome the cumulative distribution of ROH was not significantly different between cases and controls. Seven ROH at 4q22.3, 4q32.2, 7p12.3?14.1, 7p22.2, 10p11.22?23, 19q13.12-2 and 19p13.2 were associated with HL risk at P? äGenome-wide homozygosity signature and risk of Hodgkin lymphoma (epmc).pdf DeepDyve Pubget Overpricing