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10.1038/srep14218 http://scihub22266oqcxt.onion/10.1038/srep14218 C4585749!4585749 !26391588     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26391588 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26391588 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 14218 Nephropedia Template TP {{tp|p=26391588 |t=2015. Edges of human embryonic stem cell colonies display distinct mechanical properties and differentiation potential |pdf=|usr=}}{{26391588 }} gab.com Text Edges of human embryonic stem cell colonies display distinct mechanical properties and differentiation potential JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26391588 #FOAvip In order to understand the mechanisms that guide cell fate decisions during early human development, we closely examined the differentiation process in adherent colonies of human embryonic stem cells (hESCs). Live imaging of the differentiation process reveals that cells on the outer edge of the undifferentiated colony begin to differentiate first and remain on the perimeter of the colony to eventually form a band of differentiation. Strikingly, this band is of constant width in all colonies, independent of their size. Cells at the edge of undifferentiated colonies show distinct actin organization, greater myosin activity and stronger traction forces compared to cells in the interior of the colony. Increasing the number of cells at the edge of colonies by plating small colonies can increase differentiation efficiency. Our results suggest that human developmental decisions are influenced by cellular environments and can be dictated by colony geometry of hESCs. Twit Text FOAVip Edges of human embryonic stem cell colonies display distinct mechanical properties and differentiation potential ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26391588 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26391588 #FOAvip English Wikipedia <ref>{{Cite pmid|26391588 }}</ref> Edges of human embryonic stem cell colonies display distinct mechanical properties and differentiation potential #MMPMID26391588 Rosowski KA ; Mertz AF ; Norcross S ; Dufresne ER ; Horsley V Sci Rep 2015[Sep]; 5 (ä): 14218 PMID26391588 show ga In order to understand the mechanisms that guide cell fate decisions during early human development, we closely examined the differentiation process in adherent colonies of human embryonic stem cells (hESCs). Live imaging of the differentiation process reveals that cells on the outer edge of the undifferentiated colony begin to differentiate first and remain on the perimeter of the colony to eventually form a band of differentiation. Strikingly, this band is of constant width in all colonies, independent of their size. Cells at the edge of undifferentiated colonies show distinct actin organization, greater myosin activity and stronger traction forces compared to cells in the interior of the colony. Increasing the number of cells at the edge of colonies by plating small colonies can increase differentiation efficiency. Our results suggest that human developmental decisions are influenced by cellular environments and can be dictated by colony geometry of hESCs. |*Cell Differentiation [MESH] |*Colony-Forming Units Assay [MESH] |*Mechanical Phenomena [MESH] |Cytoskeleton/metabolism [MESH] |Human Embryonic Stem Cells/*cytology/*physiology [MESH]Edges of human embryonic stem cell colonies display distinct mechanica(epmc).pdf DeepDyve Pubget Overpricing