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10.1038/srep14291 http://scihub22266oqcxt.onion/10.1038/srep14291 C4585703!4585703!26387746     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26387746|t=2015. REG4 is a transcriptional target of GATA6 and is essential for colorectal tumorigenesis |pdf=|usr=}}{{26387746}} gab.com Text REG4 is a transcriptional target of GATA6 and is essential for colorectal tumorigenesis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26387746 #FOAvip The transcription factor GATA6 is a critical regulator of cell proliferation and development in the gastrointestinal tract. We have recently reported that GATA6 induces the expression of the intestinal stem cell marker LGR5 and enhances the clonogenicity and tumorigenicity of colon cancer cells, but not the growth of these cells cultured under adherent conditions. Here we show that REG4, a member of the regenerating islet-derived (REG) family, is also a target of GATA6. We further demonstrate that REG4 is downregulated by overexpression of miR-363, which suppresses GATA6 expression. Moreover, we show that GATA6-mediated activation of REG4 enhances the growth of colon cancer cells under adherent conditions and is required for their tumorigenicity. Taken together, our findings demonstrate that GATA6 simultaneously induces the expression of genes essential for the growth of colon cancer cells under adherent conditions (REG4) and genes required for their clonogenicity (LGR5), and that the miR-363-GATA6-REG4/LGR5 signaling cascade promotes the tumorigenicity of colon cancer cells. Twit Text FOAVip REG4 is a transcriptional target of GATA6 and is essential for colorectal tumorigenesis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26387746 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26387746 #FOAvip English Wikipedia <ref>{{Cite pmid|26387746}}</ref> REG4 is a transcriptional target of GATA6 and is essential for colorectal tumorigenesis #MMPMID26387746 Kawasaki Y; Matsumura K; Miyamoto M; Tsuji S; Okuno M; Suda S; Hiyoshi M; Kitayama J; Akiyama T Sci Rep 2015[]; 5 (ä): ä PMID26387746show ga The transcription factor GATA6 is a critical regulator of cell proliferation and development in the gastrointestinal tract. We have recently reported that GATA6 induces the expression of the intestinal stem cell marker LGR5 and enhances the clonogenicity and tumorigenicity of colon cancer cells, but not the growth of these cells cultured under adherent conditions. Here we show that REG4, a member of the regenerating islet-derived (REG) family, is also a target of GATA6. We further demonstrate that REG4 is downregulated by overexpression of miR-363, which suppresses GATA6 expression. Moreover, we show that GATA6-mediated activation of REG4 enhances the growth of colon cancer cells under adherent conditions and is required for their tumorigenicity. Taken together, our findings demonstrate that GATA6 simultaneously induces the expression of genes essential for the growth of colon cancer cells under adherent conditions (REG4) and genes required for their clonogenicity (LGR5), and that the miR-363-GATA6-REG4/LGR5 signaling cascade promotes the tumorigenicity of colon cancer cells. äREG4 is a transcriptional target of GATA6 and is essential for colorec(epmc).pdf DeepDyve Pubget Overpricing