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10.1038/srep14134 http://scihub22266oqcxt.onion/10.1038/srep14134 C4585672!4585672!26388493     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26388493|t=2015. A novel natural product inspired scaffold with robust neurotrophic, neurogenic and neuroprotective action |pdf=|usr=}}{{26388493}} gab.com Text A novel natural product inspired scaffold with robust neurotrophic, neurogenic and neuroprotective action JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26388493 #FOAvip In search for drugs to treat neuropsychiatric disorders wherein neurotrophic and neurogenic properties are affected, two neurotrophically active small molecules specially crafted following natural product leads based on 2-oxa-spiro[5.5]-undecane scaffold, have been thoroughly evaluated for their neurotrophic, neurogenic and neuroprotective potential in ex vivo primary culture and in vivo zebrafish and mouse models. The outcome of in vivo investigations suggest that one of these molecules is more neurotrophic than neurogenic while the other one is more neurogenic than neurotrophic and the former exhibits remarkable neuroprotection in a mouse acute ischemic stroke model. The molecular mechanisms of action of these compounds appear to be through the TrkB-MEK-ERK-CREB-BDNF pathway as pre-treatment with neurotrophin receptor TrkB inhibitor ANA-12 and MEK inhibitor PD98059 attenuates the neurotrophic action of compounds. Twit Text FOAVip A novel natural product inspired scaffold with robust neurotrophic, neurogenic and neuroprotective action ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26388493 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26388493 #FOAvip English Wikipedia <ref>{{Cite pmid|26388493}}</ref> A novel natural product inspired scaffold with robust neurotrophic, neurogenic and neuroprotective action #MMPMID26388493 Chakravarty S; Maitra S; Reddy RG; Das T; Jhelum P; Kootar S; Rajan WD; Samanta A; Samineni R; Pabbaraja S; Kernie SG; Mehta G; Kumar A Sci Rep 2015[]; 5 (ä): ä PMID26388493show ga In search for drugs to treat neuropsychiatric disorders wherein neurotrophic and neurogenic properties are affected, two neurotrophically active small molecules specially crafted following natural product leads based on 2-oxa-spiro[5.5]-undecane scaffold, have been thoroughly evaluated for their neurotrophic, neurogenic and neuroprotective potential in ex vivo primary culture and in vivo zebrafish and mouse models. The outcome of in vivo investigations suggest that one of these molecules is more neurotrophic than neurogenic while the other one is more neurogenic than neurotrophic and the former exhibits remarkable neuroprotection in a mouse acute ischemic stroke model. The molecular mechanisms of action of these compounds appear to be through the TrkB-MEK-ERK-CREB-BDNF pathway as pre-treatment with neurotrophin receptor TrkB inhibitor ANA-12 and MEK inhibitor PD98059 attenuates the neurotrophic action of compounds. äA novel natural product inspired scaffold with robust neurotrophic, ne(epmc).pdf DeepDyve Pubget Overpricing