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A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/srep13647 http://scihub22266oqcxt.onion/10.1038/srep13647 C4585377!4585377 !26380915     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26380915 &cmd=llinks): Failed to open stream: HTTP request failed! 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Full-length soluble urokinase plasminogen activator receptor down-modulates nephrin expression in podocytes |pdf=|usr=}}{{26380915 }} gab.com Text Full-length soluble urokinase plasminogen activator receptor down-modulates nephrin expression in podocytes JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26380915 #FOAvip Increased plasma level of soluble urokinase-type plasminogen activator receptor (suPAR) was associated recently with focal segmental glomerulosclerosis (FSGS). In addition, different clinical studies observed increased concentration of suPAR in various glomerular diseases and in other human pathologies with nephrotic syndromes such as HIV and Hantavirus infection, diabetes and cardiovascular disorders. Here, we show that suPAR induces nephrin down-modulation in human podocytes. This phenomenon is mediated only by full-length suPAR, is time-and dose-dependent and is associated with the suppression of Wilms' tumor 1 (WT-1) transcription factor expression. Moreover, an antagonist of ?v?3 integrin RGDfv blocked suPAR-induced suppression of nephrin. These in vitro data were confirmed in an in vivo uPAR knock out Plaur(-/-) mice model by demonstrating that the infusion of suPAR inhibits expression of nephrin and WT-1 in podocytes and induces proteinuria. This study unveiled that interaction of full-length suPAR with ?v?3 integrin expressed on podocytes results in down-modulation of nephrin that may affect kidney functionality in different human pathologies characterized by increased concentration of suPAR. Twit Text FOAVip Full-length soluble urokinase plasminogen activator receptor down-modulates nephrin expression in podocytes ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26380915 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26380915 #FOAvip English Wikipedia <ref>{{Cite pmid|26380915 }}</ref> Full-length soluble urokinase plasminogen activator receptor down-modulates nephrin expression in podocytes #MMPMID26380915 Alfano M ; Cinque P ; Giusti G ; Proietti S ; Nebuloni M ; Danese S ; D'Alessio S ; Genua M ; Portale F ; Lo Porto M ; Singhal PC ; Rastaldi MP ; Saleem MA ; Mavilio D ; Mikulak J Sci Rep 2015[Sep]; 5 (ä): 13647 PMID26380915 show ga Increased plasma level of soluble urokinase-type plasminogen activator receptor (suPAR) was associated recently with focal segmental glomerulosclerosis (FSGS). In addition, different clinical studies observed increased concentration of suPAR in various glomerular diseases and in other human pathologies with nephrotic syndromes such as HIV and Hantavirus infection, diabetes and cardiovascular disorders. Here, we show that suPAR induces nephrin down-modulation in human podocytes. This phenomenon is mediated only by full-length suPAR, is time-and dose-dependent and is associated with the suppression of Wilms' tumor 1 (WT-1) transcription factor expression. Moreover, an antagonist of ?v?3 integrin RGDfv blocked suPAR-induced suppression of nephrin. These in vitro data were confirmed in an in vivo uPAR knock out Plaur(-/-) mice model by demonstrating that the infusion of suPAR inhibits expression of nephrin and WT-1 in podocytes and induces proteinuria. This study unveiled that interaction of full-length suPAR with ?v?3 integrin expressed on podocytes results in down-modulation of nephrin that may affect kidney functionality in different human pathologies characterized by increased concentration of suPAR. |*Gene Expression Regulation [MESH] |Animals [MESH] |Down-Regulation [MESH] |Genetic Variation [MESH] |Humans [MESH] |Integrin alphaVbeta3/metabolism [MESH] |Membrane Proteins/*genetics/metabolism [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Podocytes/*metabolism [MESH] |Promoter Regions, Genetic [MESH] |Protein Binding [MESH] |Proteinuria/genetics/metabolism [MESH] |Receptors, Urokinase Plasminogen Activator/blood/genetics/*metabolism [MESH]Full-length soluble urokinase plasminogen activator receptor down-modu(epmc).pdf DeepDyve Pubget Overpricing